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leukemia

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Mind Map on leukemia, created by mahmoud eladl on 08/05/2017.
mahmoud eladl
Mind Map by mahmoud eladl, updated more than 1 year ago
mahmoud eladl
Created by mahmoud eladl almost 7 years ago
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Resource summary

leukemia
  1. occurs to
    1. White blood cells
      1. Morphology: Irregular- Multilobular nuclei
        1. Life span: 4-30 days
          1. Percentage in blood: 1%
            1. Function: Immunity against microorganisms
              1. Types
                1. granulocytes
                  1. Basophil
                    1. Eosinophil
                      1. Neutrophil
                      2. Agranulocytes
                        1. Lymphocytes
                          1. T Lymphocytes
                            1. B Lymphocytes
                              1. Plasma cells
                              2. NK cells
                              3. Monocyte
                                1. Macrophages
                            2. Content: Antibodies and granules
                              1. count
                                1. abnormalities
                                  1. leukocytosis
                                    1. causes
                                      1. Bacterial infections
                                        1. Corticosteroids
                                          1. Myocardial infarction
                                            1. Viral infections
                                              1. Autoimmune
                                                1. Malignancy
                                              2. leukocytopenia
                                        2. definition: Uncontrolled production of WBCs mainly caused by cancerous mutation.
                                          1. Risk factors
                                            1. Tobacco smoke
                                              1. Radiation exposure
                                                1. Chemotherapy and radiation therapy
                                                  1. Family history
                                                    1. congenital disorder
                                                      1. Drugs and toxins
                                                      2. Types
                                                        1. Acute Leukemia
                                                          1. AML
                                                            1. ALL
                                                            2. Chronic Leukemia
                                                              1. CLL
                                                                1. Chronic Myeloid leukemia
                                                                  1. definition: cancerous increased numbers of cells belonging to the myeloid cell
                                                                    1. Complications
                                                                      1. Pain
                                                                        1. Fatigue
                                                                          1. Enlarged Spleen
                                                                            1. Excess bleeding
                                                                              1. Infention
                                                                              2. Pathogenesis
                                                                                1. Ph chromosome : t(9;22) Translocation
                                                                                  1. oncogene ( BCR-ABL )<
                                                                                2. Phases
                                                                                  1. 1_Chronic phase
                                                                                    1. 2_ Accelerated phase
                                                                                      1. 3_ Blast phase
                                                                                      2. Risk Factors
                                                                                        1. Radiation
                                                                                          1. Age
                                                                                            1. Gender
                                                                                            2. Clinical Manifestation
                                                                                              1. Fatigue
                                                                                                1. Weight loss
                                                                                                  1. Excessive sweating
                                                                                                    1. Abdominal fullness
                                                                                                      1. Bleeding episodes
                                                                                                        1. Abdominal pain
                                                                                                        2. treatment
                                                                                                          1. TKI
                                                                                                            1. chemotherapy
                                                                                                              1. HSCT
                                                                                                                1. complications
                                                                                                                  1. -headache -nausea -pain -GVHD
                                                                                                              2. Investigations
                                                                                                                1. Bone marrow tests
                                                                                                                  1. CBC
                                                                                                                    1. Blood chemistry
                                                                                                                      1. PCR
                                                                                                                        1. FISH
                                                                                                                          1. karyotype
                                                                                                                            1. Imaging tests
                                                                                                                              1. blood smear
                                                                                                                              2. Prognosis
                                                                                                                                1. all patient treated since 2001 are alive until now and no accurate number for the years to live
                                                                                                                          2. Sign & Symptoms
                                                                                                                            1. Fever and Night sweats -Tiredness -Headaches -Joint or bone pain -Getting infections often -Losing weight and appetite
                                                                                                                              1. -Pallor -Bone tenderness -Retinal hemorrhage -Hepatosplenomegaly -Gingival involvement (AML) -Choloroma -Swollen abdomen -Swollen lymphnodes
                                                                                                                              2. Complications
                                                                                                                                1. Infections
                                                                                                                                  1. Death
                                                                                                                                    1. Richter Transformation
                                                                                                                                      1. Blood Problems
                                                                                                                                        1. Kaposis sarcoma
                                                                                                                                          1. Lung cancer
                                                                                                                                            1. Autoimmune hemolytic anemia
                                                                                                                                              1. splenomegaly
                                                                                                                                                1. causes
                                                                                                                                                  1. Infections
                                                                                                                                                    1. Hemolytic anemias
                                                                                                                                                      1. ITP
                                                                                                                                                        1. Leukemia
                                                                                                                                                          1. Lymphoma
                                                                                                                                                            1. Myeloproliferative disorders
                                                                                                                                                              1. Sarcoma
                                                                                                                                                          2. diagnosed
                                                                                                                                                            1. Blood test
                                                                                                                                                              1. Bone marrow biopsy
                                                                                                                                                                1. Lymph node biopsy
                                                                                                                                                                  1. Lumbar puncture
                                                                                                                                                                    1. Flow cytometry
                                                                                                                                                                      1. Cytogenetic and FISH
                                                                                                                                                                        1. Immunophenotyping

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