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Acute poststreptococcal glomerulonephritis

Group A streptococcal infection

Urinalysis:

Macroscopic hematuria

PRoteinuria

RBC casts

Granular casts

Other

ASO titer

Antigroup A streptococcal enzymes

Rapidly progressing glomerulonephritis

deposition of immune complexes

Goodpasture syndrome

attacks lungs and kidneys

+ antiglomerular basement membrane antibody

Wegener's granulomatosis

Vasculitis

Granuloma formation

+ ANCA

Henoch-Schonlein purpura

Primarily in children after urti

raised red patches on skin

Membranous glomerulonephritis

thickening of glomerular basement membrane

Membranoproliferative glomerulonephritis

Type 1- increase cellularity on subendothelial cells of mesangium

Type 2 - Dense deposits on GBM

Chronic glomerulonephritis

Can progress to ESRD

Nephrotic Syndrome

1. Minimal change disease

Lipid nephrosis

+ HLA - B12 ag

Common in children

Good prognosis

2. Focal segmental glomerulosclerosis

Certain numbers and area of glomeruli

+ immune deposits

Heroin analgesics AIDS

Alport syndrome

Diabetic nephropathy