Quiz
Domains & Domain Classification
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Questions in this quiz (37)
1Of known structures (60-80% of genes) how many are multidomain proteins?
- A40
- B50
- C60
- D30
2Different combinations of domains are advantageous because they allow the organism to specialise
- ATrue
- BFalse
3How can we recognize domains?
- ADNA sequencing
- BAmino acid sequencing
- CStructure
- DTopology (fold)
4Why are DNA/amino acid sequencing of little use when investigating relationships between proteins?
- AAs diversion occurs, sequence patterns are lost even as the fold remains the same
- BThey can detect short evolutionary relationships only
- CThe techniques for reading the sequences are unreliable
- DIdentical sequences can give different aa sequences/folds
5When investigating using structure, how do we identify domains?
- AAmino acid sequence
- BDomains have the same fold
- CThe interaction of the protein with other proteins
6There is a limited number of folds in nature (10^3-4)
- ATrue
- BFalse
7Structural similarity occurs from what kind of evolution?
- ADivergent
- BConvergent
8Sequence is more highly conserved than protein structure
- ATrue
- BFalse
9Define convergent evolution
- AThe independent evolution of similar features in different lineages
- BThe carrying of a feature from a common ancestor into two lines, which allows the reconvergence of the two lines into a single species again
- CThe dependent evolution of similar features in two species that interact/co-operate closely
10How does the CATH system establish taxonomy?
- ACut proteins into domains and use computor analysis to group domains
- BUses structure based analysis
11Which of the following classifications would be in the Class portion of the CATH system
- AConnectivity of fold
- BBarrel
- CMostly alpha
12Which of the following would be in the Architecture domain of the CATH system
- AMostly beta
- BBoth
- CTwo layer sandwitch
- DConnectivity of fold
- EBarrel
13Put the following in order of their use in the CATH system
A- Class
B- Sequence Superfamily
C- Homologous Superfamily
D-Architecture
E- Topology- AA-D-E-C-B
- BB-A-C-E-D
- CD-E-A-B-C
14There are 3 classes, 32 architectures and 820 topologies in the CATH system
- ATrue
- BFalse
15The SCOP classifications, in descending order, are Class-Superfamily-Family-Fold-Species
- ATrue
- BFalse
16What is the specification after Superfamiy in the Pfam system?
- AFold
- BArchitecture
- CClade
17All the systems agree in _% of cases
- A30-40
- B40-50
- C50-60
- D60-70
18To be homologous, two proteins must have two of which of the following in common?
- AStructural Similarity
- BSequence Similarity
- CFunctional Simiarity
- DSpecies Similarity
- EGenus Similarity
19What is the following describing- a protein contained in two different species with a similar function due to divergent evolution
- AOrthologues
- BParalogues
20What is the following describing- changes to a sequence following gene duplication leads to a variant copy with an additional (usually similar) function in the same species
- AOrthologues
- BParalogues
21Give the two defining features of orthologues
- ARMSD of >4
- BHigh SI
- CLow SI
- DSI may be high or low
22NAD is a co-enzyme found in all living cells that accepts and donates electrons
- ATrue
- BFalse
23NAD is made of three nucleotides and a phosphate group
- ATrue
- BFalse
24Which of the following binds NAD when present in a protein?
- AA Rossman Fold
- BA Sherman Fold
- CA Fieldman Fold
25The Rossman Fold has it's 6 beta sheets arranged in what order?
- A654123
- B123456
- C615243
26In a Rossman fold, the crossover of the strands form the binding site
- ATrue
- BFalse
27In lactate dehydrogenase, which terminal domain contains the Rossman fold?
- AC
- BN
28What is the role of the C-terminal domain in dehydrogenases?
- AEnzyme specificity
- BEnzyme regulation
- CEnzyme catalytic activity
29Lactate dehydrogenase catalyses lactate --> oxaloacetate
- ATrue
- BFalse
30Malate dehydrogenase is structually identical to LADH, so why do they have different substrates?
- AAn SI of 17%
- BThey operate in cells where only one or the other is avalible
- CLactate and malate are structurally identical, but have different components
31How can we tell two proteins are not homologues?
- AThey have a different function
- BThey have a different S.I
- CThey're found in different species
- DThey're structurally different
32What is the following descrbing- the existence of a shared ancestry between two structures (in this case proteins)
- AHomology
- BDivergent evolution
- CConvergent evolution
33Alcohol dehydrogenase contains a Rossman fold
- ATrue
- BFalse
34ADH and LDH have an RMSD of 2.2 & an S.I of 17%- what relationship do they share?
- AOrthologues
- BParalogues
35In the case of sequence diversity between proteins, surface residues change less than core/functional site residues
- ATrue
- BFalse
36Where do residue insertions usually occur?
- AIn the functional site
- BIn loops connecting secondary structures
- CIn alpha helices
37The functional diversity of a domain superfamily depends on the fold
- ATrue
- BFalse
Information
- Description
- Structural Basis for Biological Function (Basics) Quiz on Domains & Domain Classification, created by gina_evans0312 on 13/12/2013.
- Author
- gina_evans0312
- Language
- English
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