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MD5 - 6 Chemical Degradation by Oxidation and Hydrolysis

Mer Scott 9 questions

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Questions in this quiz (9)

  1. 1Select the two most common chemical degradation methods.
    1. AOxidation
    2. BHydrolysis
    3. CPhotolysis
    4. DIsomerisation
    5. EPolymerisation
  2. 2A negative slope in a pH-rate profile indicates specific [blank_start]base[blank_end] catalysis, while a positive slope indicates specific [blank_start]acid[blank_end] catalysis. A water reaction can contriute to a flat part ([blank_start]pH independent part[blank_end]) in the intermediate range of the curve, where specific catalysis still continues but is [blank_start]less prominent[blank_end] than the water reaction.
    1. Aacid
    2. Bbase
    3. CpH independent part
    4. Dless prominent
    5. Emore prominent
    6. FpH dependent part
  3. 3Label the rule of thumb factors with temperature change.Image for question 3
    1. Ax2
    2. Bx4
    3. Cx8
    4. Dx4 (2)
    5. Ex16
    6. Fx64
  4. 4A drug with an ionised and unionised form will have six degradation rate constants, k, because each form can undergo acid catalysis, base catalysis, and a reaction with water.
    1. ATrue
    2. BFalse
  5. 5Generally ionisation gives rise to more [blank_start]complex[blank_end] pH-rate profiles (not simply V-shaped curve), but [blank_start]not all reactions[blank_end] are necessarily [blank_start]significant[blank_end]. We can determine the pH-rate profile [blank_start]experimentally[blank_end] by keeping a constant temperature and changing the pH to measure rate constants.
    1. Acomplex
    2. Bnot all reactions
    3. Csignificant
    4. Dexperimentally
  6. 6B-lactams are hydrolysable groups.
    1. ATrue
    2. BFalse
  7. 7Amides are ionisable groups.
    1. ATrue
    2. BFalse
  8. 8If procaine has a hydrolysable group and two ionisable groups, and so can be unionised, mono-protonated or di-protonated, how many potential hydrolysis reactions does it have?
    1. A9
    2. B6
    3. C12
  9. 9Generally, general acid/base catalysis will lead to [blank_start]slope deviation[blank_end] (different from +/- 1) eg. buffer catalysis. Other factors, such as [blank_start]ionic strength[blank_end], may also
    lead to apparent deviations in the pH-rate profile.
    Electrolytes are often added to formulations to control [blank_start]tonicity[blank_end], and they [blank_start]increase[blank_end] the ionic strength of the formulation.
    1. Aslope deviation
    2. Bionic strength
    3. Ctonicity
    4. Dincrease

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Description
PHCY211 (Medicines) Quiz on MD5 - 6 Chemical Degradation by Oxidation and Hydrolysis, created by Mer Scott on 12/05/2018.
Author
Mer Scott
Language
English
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