Quiz
Drug Targets - Enzymes/Channels/Transporters
Questions in this quiz (34)
1When a false substrate drug acts on an enzyme, an abnormal metabolite is produced. True or false?
- ATrue
- BFalse
2Drugs can potentiate enzymes (i.e. increase their activity). True or false?
- ATrue
- BFalse
3An inactive drug is produced when a pro-drug binds to an enzyme. True or false?
- ATrue
- BFalse
4Nitric oxide stimulates what enzyme?
- AHydroxylcarboxylase
- BPhosphatase kinase
- CGuanylate cyclase
- DAcetyloxidase
5Drugs releasing nitric oxide (NO) are used to treat what?
- AAngina
- BBacterial infections
- CAsthma
- DStomach ulcers
6Which of the following drugs inhibits cyclo-oxygenase?
- AFluoxetine
- BParacetamol
- CAspirin
- DQuinine
7Which of the following drugs inhibits phosphodiesterase?
- AAspirin
- BCaffeine
- CParacetamol
- DTetracycline
8What roles does the drug Aspirin play?
- AAnticoagulant
- BAnalgesic
- CAnti-inflammatory
- DAntipyrectic
9Aspirin is a reversible enzyme inhibitor. True or false?
- ATrue
- BFalse
10What is the function of the enzyme cyclo-oxygenase?
- AConverts arachidonic acid into prostaglandins
- BAdds a phosphate group to adenine diphosphate
- COxidises a cyclic organic molecule
- DRemoves an oxygen group form a cyclic organic molecule
11When Aspirin inhbits cyclo-oxygenase, what cellular effects are affected?
- AInflammation
- BPain
- CVascular tone (contractile activity of smooth muscle in small arteries and arterioles)
- DPlatelet function (prevents bleeding)
12Which of the following statements are true about L-DOPA (levodopa)?
- APrevents symptoms of rigidty and tremor
- BIncreases the level of dopamine in the body
- CActivates an enzyme to produce more dopamine
- DCan be used to treat Parkinson's disease
13In Parkinson's disease, there are reduced levels of what neurotransmitter in what part of the brain?
- ADopamine, cerebrum
- BAcetylcholine, basal ganglia
- CDopamine, basal ganglia
- DAcetylcholine, cerebrum
14Why can L-DOPA be used to treat Parkinson's disease?
- AIt enters the peripheral nervous system
- BL-DOPA can cross the blood-brain barrier
- CL-DOPA is the immediate precursor of dopamine
- DIt acts directly upon muscles to prevent symptoms of rigidity and tremor
15Which of the following statements are true regarding the properties of L-DOPA and dopamine?
- ADOPA-decarboxylase acts upon L-DOPA to produce dopamine
- BL-DOPA and dopamine can cross the blood-brain barrier
- CRemoving a carboxylic acid group from L-DOPA forms the neurotransmitter, dopamine
- DDopamine can be used to prevent symptoms of Parkinson's disease
16L-DOPA is administered as a medicine. Given alone, dopamine levels would increase in the brain and periphery. How may this be prevented?
- AAdminister L-DOPA in very small quantities
- BCo-administering a DOPA-decarboxylase inhibitor (e.g. carbidopa)
- CClosely monitor L-DOPA levels in the body once administered
- DCo-administer with an enzyme that removes dopamine from the body
17Carbidopa does not cross the blood brain barrier. Therefore dopamine concentrations are only increased in the brain. True or false?
- ATrue
- BFalse
18Neostigmine is an example of what?
- AAn anticoagulant
- BAn analgesic
- CA neurotransmitter
- DAn anti-cholinesterase
19Treatment with anti-cholinesterases boosts the effects of acetylcholine. True or false?
- ATrue
- BFalse
20In general anaesthesia, the action of nicotinic acetylcholine receptors is stimulated. True or false?
- ATrue
- BFalse
21What effects does inhibiting cholinesterase have?
- APrevents acetylcholine breakdown
- BBlocks the action of nicotinic acetylcholine receptors
- CIndirectly increases acetylcholine concentration
- DDisplaces the receptor blocker (a competitive antagonist) from the receptor, reversing its effects
22Which of the following statements are true regarding the disease Myasthenia gravis?
- AMuscles that control swallowing are unaffected by the disease
- BIt is an auto-immune disease in which antibodies develop against the muscle nicotinic Ach receptor
- CIt is treated with anti-cholinesterases to boost the action of Ach
- DSymptoms of the disease include drooping eyelids and muscle weakness
23Ion channel blockers allow permeation. True or false?
- ATrue
- BFalse
24Ion channel modulators increase/decrease opening probability. True or false?
- ATrue
- BFalse
25Which of the following is false: ion channels are grouped by
- AOverall charge
- BHow they open (i.e. pressure, voltage)
- CIon selectivity
- DTheir molecular structure
26What is the function of verapamil?
- AActs as a competitive agonist
- BBlocks calcium channels
- COpens potassium channels
- DInhibits nicotinic receptors
27Calcium ion channel blockers are used to treat which of the following?
- AHypertension
- BAngina
- CHeart failure
- DArrythmia
28Which of the following statements is false regarding sodium ion channel blockers?
- AInhibits influx of sodium, preventing action potential propagation
- BLidocaine is an example of a sodium ion channel blocker
- CVerapamil is an example of a sodium ion channel blocker
- DSodium channel blockers act as local anasethetics
29Transporters move ions down their electrochemical gradient. True or false?
- ATrue
- BFalse
30The action of transporters requires energy from
- AATP hydrolysis (active transport)
- BBorrowing energy from other biochemical reactions (pre-transport)
- CUtilising an existing ion gradient (co-transport)
- DEnergy is not required for the action of transporters
31Which drug blocks Na+/K+ ATPase to treat heart failure?
- AFluoxetine
- BLidocaine
- CDopamine
- DDigoxin
32Fluoxetine is an example of
- AAn anticoagulant
- BAn antidepressant
- CA local anaesthetic
- DAn antipyretic
33The drug Fluoxetine is an example of a Serotonin-Selective Reuptake Inhibitor (SSRI). True or false?
- ATrue
- BFalse
34Treatment with Serotonin-Selective Reuptake Inhibitors (SSRIs) increases the effects of the 5HT receptor. True or false?
- ATrue
- BFalse
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- University Physiology and Pharmacology Quiz on Drug Targets - Enzymes/Channels/Transporters, created by Becca Shaw on 07/05/2015.
- Author
- Becca Shaw
- Language
- English
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