Flashcards
Citric Acid Cycle
Cards in this deck (17)
- 1What is the input for the citric acid cycle?Acetly-Co A
- 2What happens?Acetate enters the cycle, CoAsh released to be reused
- 3What is first formed and how?Oxaloacetate and acetate combined to form citrate
uses citrate synthase - 4What is formed from citrate?Isocitrate
aconitase - 5What is formed from isocitrate?Alphaketoglutarate
(AKA 2-oxoglutarate)
NADH formed
CO2 released
Isocitrate dehydrogenase - 6What is formed from alpha ketoglutarate?Succinyl CoA
CoAsh added
CO2 removed
NADH produced
Oxoglutarate dehydrogenase - 7What is formed from Succinyl Co A?Succinate
GTP produced
Succinate thiokinase - 8What is produced from succinate?Fumerate
FADH2 produced
Succinate dehydrogenase - 9What is produced from fumerate?Malate
H2O added
Fumerase - 10What is produced from malate?Oxaloacetate
NADH produced
Malate dehydrogenase - 11Purine Nucleotide CycleOxaloacetate rate-limiting if much acetyl-CoA.
Breakdown of ATP in strenuous exercise generates fumerate to produce more oxaloacetate - 12How is citrate synthase controlled?Allosterically inhibited by ATP
- 13Why is citrate synthase regulation important?Gluconeogenesis.
Inhibited by hight [ATP].
Oxaloacetate directed to gluconeogenesis and acetyl-CoA for ketone bodies to fuel brain - 14How is isocitrate dehydrogenase regulated?Inhibited by ATP and NADH in fed state
- 15How is oxoglutarate dehydrogenase controlled?Inhibited by NADH and succinyl CoA
Stimulated by Ca2+ - 16How is Acetyl CoA produced?Pyruvate dehydrogenase
- 17How is pyruvate dehydrogenase controlledInhibited by pyruvate
Stimulated by Ca2+ - "on" in exercise
Regulated by ratio of NADH/NAD+ and acetlycoA/coA
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- Biology of Cells IA (Metabolism Pathways) Flashcards on Citric Acid Cycle, created by Alice Hathaway on 04/01/2019.
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- Alice Hathaway
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