Antibiotics MCQs

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Antibiotics MCQs
Jess Pope
Test por Jess Pope, actualizado hace más de 1 año
Jess Pope
Creado por Jess Pope hace más de 7 años
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Resumen del Recurso

Pregunta 1

Pregunta
Bactericidal drugs kill bacteria.
Respuesta
  • True
  • False

Pregunta 2

Pregunta
Which class of drugs slows bacterial growth?
Respuesta
  • Bactericidal
  • Bacteriostatic

Pregunta 3

Pregunta
When a bacteriostatic drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?
Respuesta
  • Increase
  • Decrease
  • Stay the same

Pregunta 4

Pregunta
When a bactericidal drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?
Respuesta
  • Increase
  • Decrease
  • Stay the same

Pregunta 5

Pregunta
When a bacteriostatic drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?
Respuesta
  • Increase
  • Decrease
  • Stay the same

Pregunta 6

Pregunta
When a bactericidal drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?
Respuesta
  • Increase
  • Decrease
  • Stay the same

Pregunta 7

Pregunta
Are the actions of sulphonamides bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 8

Pregunta
Is the action of trimethaprim bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 9

Pregunta
Are the actions of tetracyclines bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 10

Pregunta
Is the action of chloramphenicol bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 11

Pregunta
Is the action of linomycin bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 12

Pregunta
Is the action of erythromycin (macrolides) bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 13

Pregunta
Are the actions of penicillins bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 14

Pregunta
Are the actions of cephalosporins bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 15

Pregunta
Are the actions of fluoroquinolones bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 16

Pregunta
Are the actions of aminoglycosides bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 17

Pregunta
Is the action of metronidazole bactericidal or bacteriostatic?
Respuesta
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Pregunta 18

Pregunta
A potentiated sulphonamide refers to which of the following combinations of antibacterial agents?
Respuesta
  • Sulphonamide and Erythromycin
  • Sulphonamide and Fluoroquinolone
  • Sulphonamide and Trimethoprim
  • Sulphonamide and Chloramphenicol
  • Sulphonamide and Cephalosporin

Pregunta 19

Pregunta
What is the main aim for optimum efficacy of a time dependent drug?
Respuesta
  • Plasma levels should be above minimum inhibitory concentration (MIC) for as long as possible in each 24 hour period
  • Plasma levels should be as high as possible for as long as possible
  • The dosage is irrelevant, but the drug must be in the system for as long as possible

Pregunta 20

Pregunta
Which of the following drugs is time dependent?
Respuesta
  • Aminoglycoside
  • Penicillin
  • Fluoroquinolones
  • Metronidazole

Pregunta 21

Pregunta
Which of the following drugs is time dependent?
Respuesta
  • Aminoglycoside
  • Cephalosporin
  • Fluoroquinolone
  • Metronidazole

Pregunta 22

Pregunta
Which of the following drugs are concentration dependent?
Respuesta
  • Penicillin
  • Aminoglycoside
  • Metronidasole
  • Cephalosporin
  • Fluoroquinolone

Pregunta 23

Pregunta
Where are NAMA and NAG synthesised?
Respuesta
  • Cytoplasm
  • Membrane
  • Extra-membrane

Pregunta 24

Pregunta
How many peptides are initially attached to NAMA?
Respuesta
  • 3
  • 4
  • 5
  • 6

Pregunta 25

Pregunta
What is the most important feature for the activity of a penicillin/cephalosporin?
Respuesta
  • Ring of 2 carbons and 2 nitrogens
  • Ring of 3 carbons and 1 nitrogen
  • Ring of 5 carbons
  • Ring of 5 carbons and 1 nitrogen
  • Ring of 4 carbons and 2 nitrogens

Pregunta 26

Pregunta
What determines the antibacterial activity of β-lactams?
Respuesta
  • R side chain
  • Ability to bind to peptidyl transferase
  • Ability to bind to transpeptidases
  • Drug size
  • Ability to bind to gamma-glutamyl transpeptidase

Pregunta 27

Pregunta
The ability for penicillin to access transpeptidase is limited in gram +ve bacteria.
Respuesta
  • True
  • False

Pregunta 28

Pregunta
Clavulanic acid has an antibacterial effect when administered alone.
Respuesta
  • True
  • False

Pregunta 29

Pregunta
Which of the following drugs would be best paired with clavulanic acid?
Respuesta
  • Mecillinam
  • Cloxacillin
  • Benzylpenicillin
  • Methicillin
  • Amoxicillin

Pregunta 30

Pregunta
Benzylpenicillin has good acid stability.
Respuesta
  • True
  • False

Pregunta 31

Pregunta
Which of the following drugs are susceptible to β-lactamase activity?
Respuesta
  • Benzylpenicillin
  • Penicillin V
  • Cloxacillin
  • Methicillin
  • Ampicillin
  • Amoxicillin
  • Carbenicillin
  • Mecillinam

Pregunta 32

Pregunta
Which of the following drugs are not susceptible to β-lactamase activity?
Respuesta
  • Cloxacillin
  • Benzylpenicillin
  • Methicillin
  • Mecillinam
  • Carbenicillin

Pregunta 33

Pregunta
Which of the following drugs are most effective against Gram +ve cocci?
Respuesta
  • Benzylpenicillin
  • Mecillinam
  • Penicillin V
  • Cloxacillin
  • Methicillin

Pregunta 34

Pregunta
Which of the following drugs is most active against Gram -ve bacteria?
Respuesta
  • Mecillinam
  • Methicillin
  • Cloxacillin
  • Carbenicillin

Pregunta 35

Pregunta
Which of the following drugs is efficacious against pseudomonas?
Respuesta
  • Mecillinam
  • Cloxacillin
  • Carbenicillin
  • Methicillin

Pregunta 36

Pregunta
Which generations of cephalosporins are unstable in acid?
Respuesta
  • 1st generation
  • 2nd generation
  • 3rd generation
  • 4th generation

Pregunta 37

Pregunta
Which generation of cephalosporin has the least β-lactamase stability?
Respuesta
  • 1st generation
  • 2nd generation
  • 3rd generation
  • 4th generation

Pregunta 38

Pregunta
Which generations of cephalosporin are least susceptible to β-lactamase activity?
Respuesta
  • 1st generation
  • 2nd generation
  • 3rd generation
  • 4th generation

Pregunta 39

Pregunta
Which of the following drugs is most efficacious against gram +ve bacteria?
Respuesta
  • Cephalexin
  • Cefuroxime
  • Cefovecin
  • Cefquinome

Pregunta 40

Pregunta
Which of the following drugs is most efficacious against gram -ve bacteria?
Respuesta
  • Cephradine
  • Cephalexin
  • Cefquinome
  • Cefovecin

Pregunta 41

Pregunta
Which of the following drugs is efficacious against pseudomonas?
Respuesta
  • Cephradine
  • Cefovecin
  • Cefquinome
  • Cefuroxime

Pregunta 42

Pregunta
Penicillins and cephalosporins are eliminated by the liver.
Respuesta
  • True
  • False

Pregunta 43

Pregunta
Penicillins do not cross the BBB, despite being widely distributed.
Respuesta
  • True
  • False

Pregunta 44

Pregunta
Some cephalosporins cross the BBB.
Respuesta
  • True
  • False

Pregunta 45

Pregunta
Aminoglycosides induce a long lasting mutation in bacteria, so are risky to use given that resistance may easily occur.
Respuesta
  • True
  • False

Pregunta 46

Pregunta
What type of bacteria are aminoglycosides more efficacious against?
Respuesta
  • Gram -ve anaerobic bacteria
  • Gram -ve aerobic bacteria
  • Gram +ve anaerobic bacteria
  • Gram +ve aerobic bacteria

Pregunta 47

Pregunta
Aminoglycosides are typically bactericidal.
Respuesta
  • True
  • False

Pregunta 48

Pregunta
Aminoglycosides have poor oral bioavailability.
Respuesta
  • True
  • False

Pregunta 49

Pregunta
How are aminoglycosides eliminated from the body?
Respuesta
  • Liver metabolism
  • Renal excretion
  • Excreted in bile
  • Metabolism in muscles

Pregunta 50

Pregunta
How do macrocodes inhibit bacteria protein synthesis?
Respuesta
  • Bind to ‘A’ site, prevent initiation
  • Bind to ‘P’ site, prevent translocation
  • Bind to ‘E’ site, prevent translocation
  • Bind to ‘A’ site, prevent termination

Pregunta 51

Pregunta
What type of bacteria are macrocodes more efficacious against?
Respuesta
  • Gram -ve
  • Gram +ve

Pregunta 52

Pregunta
Macrocodes have poor oral bioavailability.
Respuesta
  • True
  • False

Pregunta 53

Pregunta
How are macrolides eliminated from he body?
Respuesta
  • Metabolised by liver
  • Renal excretion
  • Excreted in bile
  • Metabolism in muscles

Pregunta 54

Pregunta
At doses normally used in veterinary practice, erythromycin is bactericidal.
Respuesta
  • True
  • False

Pregunta 55

Pregunta
How do lincosamides inhibit bacteria protein synthesis?
Respuesta
  • Bind to 'A' site, prevent initiation
  • Bind to 'P' site, prevent elongation
  • Bind to 'E' site, prevent elongation
  • Bind to 'E' site, prevent termination

Pregunta 56

Pregunta
How do tetracyclines inhibit bacterial protein synthesis?
Respuesta
  • Bind to 'A' site, prevent initiation
  • Bind to 'P' site, prevent elongation
  • Bind to 'E' site, prevent elongation
  • Bind to 'E' site, prevent termination

Pregunta 57

Pregunta
Which class of bacteria are tetracyclines most effective against?
Respuesta
  • Gram +ve aerobes
  • Gram +ve anaerobes
  • Gram -ve aerobes
  • Gram -ve anaerobes
  • Wide spectrum against aerobic and anaerobic Gram +ve and –ve bacteria

Pregunta 58

Pregunta
Tetracyclines have a bacteriostatic effect.
Respuesta
  • True
  • False

Pregunta 59

Pregunta
How are tetracyclines eliminated from the body?
Respuesta
  • Metabolism by the liver
  • Renal excretion
  • Excreted in bile
  • Metabolism by muscles

Pregunta 60

Pregunta
Tetracyclines inhibit mammalian protein synthesis. Why are the side effects not more severe than those observed if this is the case?
Respuesta
  • The drug is delivered directly to the site of action, minimising the systematic effect
  • The concentration is not high enough to affect mammalian cells
  • Mammalian cells do not efficiently transport tetracyclines across cell membrane
  • Tetracyclines on affect cells with a cell wall

Pregunta 61

Pregunta
How does chloramphenicol inhibit bacterial protein synthesis?
Respuesta
  • Binds to 'A' site, inhibits initiation
  • Binds to 'P' site, inhibits elongation
  • Inhibits peptide bond formation
  • Binds to 'E' site, inhibits termination

Pregunta 62

Pregunta
Chloramphenicol is banned in food-producing animals
Respuesta
  • True
  • False

Pregunta 63

Pregunta
Chloramphenicol had poor oral bioavailability.
Respuesta
  • True
  • False

Pregunta 64

Pregunta
Chloramphenicol can cross the BBB.
Respuesta
  • True
  • False

Pregunta 65

Pregunta
Chloramphenicol has a bacteriocidal effect.
Respuesta
  • True
  • False

Pregunta 66

Pregunta
How is chloramphenicol eliminated from the body?
Respuesta
  • Liver metabolism
  • Renal excretion
  • Excreted in bile
  • Metabolised in muscles

Pregunta 67

Pregunta
In which class of bacteria is chloramphenicol most efficacious?
Respuesta
  • Gram positive aerobes
  • Gram negative aerobes
  • Obligate anaerobes
  • Penicillinase producing - Staphylococcus

Pregunta 68

Pregunta
Which of the following drugs affect folate synthesis?
Respuesta
  • Cyclosporins
  • Chloramphenicol
  • Sulphonamides
  • Tetracycline
  • Trimethoprim

Pregunta 69

Pregunta
Which class of bacteria are sulphonamides most efficacious against?
Respuesta
  • Gram -ve anaerobes
  • Gram - aerobes
  • Gram +ve anaerobes
  • Gram +ve aerobes
  • Wide spectrum against Gram +ve and –ve bacteria

Pregunta 70

Pregunta
Sulphonamides have poor oral bioavailability.
Respuesta
  • True
  • False

Pregunta 71

Pregunta
Sulphonamides can cross the BBB.
Respuesta
  • True
  • False

Pregunta 72

Pregunta
How are sulphonamides excreted from the body?
Respuesta
  • Metabolised by the liver
  • Renal excretion
  • Excreted in bile
  • Metabolised by muscles

Pregunta 73

Pregunta
Sulphonamides have a bacteriostatic effect.
Respuesta
  • True
  • False

Pregunta 74

Pregunta
How does trimethoprim affect bacterial folate synthesis?
Respuesta
  • Inhibits uptake of p-aminobenzoic acid (PABA)
  • Inhibits dihydropteroate synthetase (DHPS)
  • Inhibits dihydropteroate reductase (DHPR)
  • Inhibits dihydrofolate synthetase (DHFS)
  • Inhibits dihydrofolate reductase (DHFR)

Pregunta 75

Pregunta
How are fluoroquinolones eliminated form the body?
Respuesta
  • Metabolised by liver
  • Renal excretion
  • Excreted in bile
  • Metabolised by muscles

Pregunta 76

Pregunta
Fluoroquinolones have poor oral bioavailability
Respuesta
  • True
  • False

Pregunta 77

Pregunta
Fluoroquinolones have a bactericidal effect.
Respuesta
  • True
  • False

Pregunta 78

Pregunta
Which class of bacteria is metronidazole most efficacious against?
Respuesta
  • Gram positive aerobes
  • Gram negative aerobes
  • Obligate anaerobes
  • Penicillinase producing Staphylococcus

Pregunta 79

Pregunta
Metronidazole has good oral bioavailability
Respuesta
  • True
  • False

Pregunta 80

Pregunta
Metronidazole can cross the BBB.
Respuesta
  • True
  • False

Pregunta 81

Pregunta
How is metronidazole eliminated from the body?
Respuesta
  • Metabolised by the liver
  • Renal excretion
  • Biliary excretion
  • Metabolised by muscles
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