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lecture 15
Fichas del conjunto (17)
- 1what are pathogensmicrobes that are capable of causing damage to the host
- 2what is infectionscolonisation/invasion of a host by a pathogen
- 3what do bacteria or pathogens need to do to cause an infectioncolonise the host
evade host defences
proliferate
cause damage - 4for colonisation, what do you need to consider?source
transmission
risk factors - 5bacterial adherence is needed toprevent bacteria from being washed away
adherance to a preferred niche
prelude of cellular invasion or toxic production - 6what types of bacterial adhesions molecules are therenon specific adhesion molecules
specific adhesion molecules - 7what do non specific molecules often dooften give reversible binding
examples are teichoic acids of Staph A
or the alginate capsule of pseudomonas aeruginosa - 8what is an example of specific adhesionsgram negative bacteria - pili and fimbriae and outer membrane adhesions
gram positive bacteria have cell wall proteins e.g. MSCRAMMs bind matrix proteins - 9what are some of the host defencesskin and mucous barrier
antibacterial compunds in secretions
iron restrictions
complement
phagocytes
antibody responses - 10what is masking and hidingthe microbe hides from the immune system beneath a barrier
- 11what is mimicrythe microbe appears as self to the immune system
- 12what is destructionthe microbe attacks the immune system by producing toxins that kill phagocytes and enzymes that degrade immune molecules
- 13what is mis informationthe microbes sends false signals and decoys which confuse the host
- 14what does iron have to do with proliferationiron is needed by bacteria as it is a cofactor for many essential enzymes however it is not readily available like many other nutrients in the body
- 15how is access to iron restricted by the bodylactoferrin in secretions
transferrin in the blood
functional in enzymes
stored as ferritin in cells - 16how do pathogenic bacteria overcome iron restrictionssiderophores which are iron chelators released by bacteria
specific binding proteins - for transferring
increasing the iron that is available - haemolysin and protease activity
adapting to a high iron niche of phagosomes
envolving enzymes that use other co factors e.g. Mn - 17—
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- Fichas sobre lecture 15, creado por nileesha Parbhu el 26/10/2014.
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- nileesha Parbhu
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