Fichas
Pharmacology of the immune system drugs
Fichas del conjunto (30)
- 1Fostamatinib R343Syk inhibitors
- 2RilonaceptIL-1 trap (FOAS)
- 3AnakinraRecombinant IL-1ra
- 4PralnacasanICE inhibitor (oral)
- 5VercinironCCR9 blocker - Tc in gut for chromes
- 6MarimastatTACE/MMP inhibitor
(MS SE) - 7NFkB inhibitors for TNFaglucocorticoids
thalidomide
curcumin - 8ErtanerceptTNFR Ab fusion protein
- 9Rituximab MEDI-155CD20 on Bc
- 10Zielutoninhibits leukotrienes
- 11Infliximabanti-TNF mAb
(hu Fc & mu Fv) - 12AdalimumabFully hu anti-TNF
- 13certolizumab pegolPEGylated Fab fragment of TNFa
- 14PEGylation↑ stability
↓ renal clearnace - 15Drawbacks of immunotherapy for TNFa- immunogenic (∴ humanise)
- short plasma T1/2 (∴ PEG)
- need to IV admin
- Infection risks (latent TB)
- expensive - 16OnerceptPEG TNF binding protein
(discontinued) - 17RuxolitinibJAK 1/2 inhibitor
- 18TofacitinibOrally active JAK inhibitor (RA w/ MTX)
- 19nedocromilsodium cromoglycate
topical for nose & eyes
Mast cell stablaliser: inhibit mediator release
only effective in 50% of population
but treats early and late phase asthma - 20prednisolone budsonideinhibits NFkB ∴ leuk migration via chemotaxis
glucocorticoids - 21Altrakinceptsoluable recombinant IL-4
dissapointing PIII - 22PitrakinraIL-4 variant
↓ late phase responses - 23Librikizumabanti-IL-13 mAb
effects secretion of epithelium
only really helps FEV1 improvements - 24Ustekinumabhu mAb
- 25ketotifenH1 antagonist & mast cell stabliser
opthalmic and oral
also leukotriene and PDE antagonist
Maybe H4 activity: chemotaxis - 26Omalizumabanti-IgE
for allergic athmatics: NICE in sterioid resistants
binds Fc
needs to be taken for a while and expensive - 27anti-IL-4Altrakincept: soluable recombinant IL-4 receptor
Pitrakinra: IL-4 variant - 28LebrikizumabIL-13 mAb
effects secretion of epithelium - 29Mepolizumabanti-IL5 for eosinophilic dermatis
- 30BraikinumabIL-12/23 mAb
Información
- Descripción
- Fichas sobre Pharmacology of the immune system drugs, creado por Livvi Harris el 25/04/2014.
- Creado por
- Livvi Harris · abr 2014
- Actualizado
- 10 abr 2016
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- 87
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