Inflammation through tissue damage

Inflammation through tissue damage

1. Endothelial Damage

   • Activation of Hageman Factor (XII)
     • Prekallikrein
       • Kallikrein
         • Kinninogen --> Bradykinin
           • Increase in vascular permeability. Vasodilation. Pain. Smooth muscle contraction
     • Activated clotting cascade
       • Thrombin
         • Fibrinopeptides and Fibrin Clot
       • Activated fibrinolytic system
         • Plasmin
           • Fibrinopeptides and fibrin clot
             • Fibrin Degredation
               • Increase in vascular permeability. Neutrophil chemotaxis
           • Complement Activation
             • Anaphylatoxins C3a, C5a
               • Extravasion of monocytes and neutrophis to the site of complement activation
               • Mast Cell Degredation
                 • Increase in vascular permeability. Smooth muscle contractions