Therapeutic Index

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therapeutic index: disease cured, measurable improvement

ex 1. diabetes - decrease blood glucose

ex 2. hypertension- decrease in blood pressure

**therapeutic index not affected by half life of the drug

** save drugs have a ti of > 1000

The graph: therapeutic index(ti)= LD5/ED95

LD5(lethal dose): dose that is lethal to 5% of the population

ED95(effective dose): dose that produces a therapeutic response or desired effect in 95% of the population

x (horizontal)- the dose of the drug

y (vertical)- % patients responding

black: therapeutic

red: toxic effect (death or some kind of severe side effects)