Fichas
Drugs to remember Pharm 3
Fichas del conjunto (18)
- 1TetrahydrocannabinolTHC, compound from Cannabis
psychotropic element
partial agonist at CB1 in CNS and CB2 in immune system.
The psychoactive effects of THC from activation of CBs; leads to decrease in the concentration of the second messenger molecule cAMP through inhibition of adenylate cyclase
positive allosteric modulator of the μ- and δ-opioid receptors - 2endocannabinoidslipid mediators
- 3Cannabidiolpositive allosteric modulator of the μ- and δ-opioid receptors, producing analgesia
? anticonvulsant
? anti-inflammatory
isomer of THC
CB2 - 4Cannabinolmetabolite of THC
CB2 - 5Barbituatespositive allosteric modualator of GABA
increases the duration of opening time of the chloride channel
reduces neuronal excitability and action potential frequency at the epileptic focus.
(phenobarbital effects on Na+ and Ca+ channels may contribute to the anticonvulsant activity) - 6Temazepambenzodiazapine
positive allosteric modulator of GABA
benzodiazepines increase the frequency of the opening of the Chloride channel => increasing activity of GABA. increased Cl- permeability reduces electrical excitability. - 7ImidazopyradinesGABAa agonist
non-benzodiazepine - 8Flumazenilcompetitive antagonist at Benzo binding site on GABAa receptor
- 9Ketaminedissociative anaesthesia in which the patient ay remain conscious but have good pain relief and short term amnesia.
used recreationally for dissociative, hallucinogenic, and euphoriant properties
NMDA type glutamate receptor ion channel blocker.
NMDA receptor antagonist
also interacts with muscarinic receptors, descending pain pathways, voltage-sensitive calcium channels and opioid receptors in brain and spinal cord.
medically used to start and maintain anaesthesia - 10Dextromethorphanantitussive with sedating properties
opioid derivative - 11Memantinenovel class of drug to treat Alzheimer's disease
ameliorates symptoms
NMDA antagonist; open channel block of NMDA receptors; prevents Na+ and Ca2+ entry into the neurone, reducing glutamate excitotoxicity. may reduce glutamate induced neural-degradation
"decrease noise" - 12Buspironepartial agonist at serotonin 5HT-1A receptor - acts presynaptically to inhibit firing of serotonergic neurons, particularly in the dorsal raphe nucleus.
anxiolytic - 13Ondansetron5HT-3 antagonist =>
central and peripheral 5HT3 blockade
anti-emetic - 14Sumatriptan5HT-1B/1D agonist
antimigraine - 15clozapine5HT -2/6/7 * (serotonin) antagonist
- 16SelegilineIrreversibly inhibit monoamine oxidase type B (MAO‐B); they reduce breakdown of dopamine and may also block dopamine reuptake. - Parkinson's Disease
potentiate action of endogenous dopamine and dopamine formed form administered levodopa
MAO is in the neuron - 17Entacaponereversibly inhibits catechol-O‐methyltransferase (COMT), mainly in peripheral tissues; increases the amount of levodopa available to the brain and prolongs the clinical response to levodopa.
synergises with antiparkinsonian effects of levodopa and potentiates the actions of catecholamines. - 18Propanolol.