46705
Description
Flashcards by Mark Arsenal, updated more than 1 year ago
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Created by Mark Arsenal
about 11 years ago
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| Question | Answer |
| What factors inhibit Pyruvte Dehyrodgenase? | High levels of NADH or NAD, High levels of Acetyl Co-A, High levels of ATP/ADP. |
| Anaplerosis: | Series of enzymatic reactions that replenish intermediates. |
| What factors stimulate Pyruvate Dehydrogenase? | Non-Acetylated CoA and NAD+. |
| Cataplerosis: | Series of enzymatic reactions that remove intermediates. |
| Does TCA Intermediate availability play any role in causing fatigue? | No. TCA intermediates never fall below a certain point thus not a cause of fatigue. |
| What does the Alanine Aminotransferase Reaction do? | It generates TCA intermediates at the onset of exercise. |
| TCA cycle is regulated by: | Intermediate availability. Acetyl CoA availability. The enzymes are controlled by Ca, ATP and ADP. |
| What do we breakdown and form in TCA cycle?? | We break down Pyruvate into energy rich NADH and FADH (for breakdown in ETC) |
| Where does the TCA take place? | Mitochondrial Matrix of the Cell |
| What do we get from TCA? | 3 NADH, 1 FADH, 1 GTP and 2 CO2 |
| What is GTP? | Guanosine Triphosphate. It helps us make ATP. It costs 2 GTP per 8 cycles of the TCA. Thus in 8 cycles we get 6 ATP. |
| Does Pyruvate have to be broken down before entering the TCA cycle? | Yes- It is broken down to Acetyl-CoA by Pyruvate Dehydrogenase. |
| Intermediates of TCA: | Acetyl CoA, Citrate, Isocitrate, Alpha Ketoglutarate, Succinyl CoA, Succinate, Fumarate, Malate, Oxaloacetate. |
| Enzymes of TCA Cycle: | Citrate Synthase, Aconitase Isocitrate Dehydrogenase, Alpha Ketoglutarate Dehydrogenase, Succinyl CoA Synthetase, Succinate Dehydrogenase, Fumarase, Malate Dehydrogenase. |
| What is the process? | Through a series of reactions we cleave 2 carbon atoms from a 6 carbon atom substance. This is Citrate- formed from 2 carbon atom Acetyl CoA and 4 carbon atom Oxaloacetate) |
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