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Description
Flashcards by Anuarruddin Azmilumur, updated more than 1 year ago
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Created by Anuarruddin Azmilumur
about 8 years ago
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| Question | Answer |
| What is immune system? | Network of cells, tissues, organs in body that work together in protecting from infection |
| Divided into two types | Innate Immune Response (1st & 2nd Line Defense) Adaptive Immune Response (3rd Line Defense) |
| Components in immune system | 1. Cardiovascular system 2. Reticuloendothelial system (MPS) 3. Lymphatic system |
| Cardiovascular System | |
| Reticuloendothelial System | |
| Lymphatic System | |
| Function of Organs in Lymphatic System | Primary - where lymphocytes are formed and mature (Bone marrow, thymus) Secondary - arranged as a series of filters monitoring the contents of the extracellular fluids - where lymphocytes are activated. |
| Cells of the immune system | |
| What is Innate Immune Response? | - Non-specific - Immune components are preformed - Response magnitude similar between first & second infection - No memory stored |
| First Line of Defense (Physical Barriers) | |
| Second Line of Defense (Physiological Barriers) | 1. Fever (induced by pyrogens) 2. Inflammation 3. Phagocytosis 4. Antimicrobial proteins |
| What is benefit of fever? | - Reduced iron availability - Inhibit microbial multiplication - Stimulate immune response |
| How does inflammation works? | |
| Phases of Phagocytosis | |
| Antimicrobial proteins divided into 4 main types: | 1. Complement system 2. Interferons 3. Iron-binding system 4. Antimicrobial peptides |
| Complement system: Overview | |
| Mode of action of interferons (IFN-α IFN-β IFN-γ) | |
| Why iron-binding system? (Haemoglobin, Lactoferrin, Transferrin) | - Able to inhibit enzyme activites of pathogens - Most of them require iron - They can overcome with siderophore |
| Antimicrobial peptides |
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