Flashcards
Protein Structure
Cards in this deck (9)
- 1Collagen25% of body protein, a 3 parallel chain helix, where a G is every 3rd residue, proline/lysine rich, pro is hydroxylated to keep shape
- 2Osteogensis ImperfectaG988->Cys in collagen leading to brittle bones
- 3ScurvyAscorbic Acid (vitamin C) low - > it hydroxylates the prolines
- 4Elastina long protein of tropoelastin and glycoprotein - demosine cross links allow for elasticity
- 5BPGintermediate in glycolytic RBC path that shifts Hb curve into physologically relevant range, binds T state to dec. O2 affinity - very negative!!
- 6Fetal Hbhigh O2 affinity not by nature but by not binding BPG as well
- 7Bohr EffectMetabolizing tissues make CO2 and protons, both which stabilize the T state leading to O2 release (so high pH, exercising leads to dropping O2)
- 8Sickle Cell Anemia - Molecular LevelMutation on B6 glu ->val [T->A] so that Hb solubility decreases in the deoxy state -> fibers -> sickle shape (this self-perpeptuates)
a 14 strand fiber with B6 val sequestered w/in - 9Sickle Cell Anemia crisislow Oxygen (surgery, hypoxia)
Low pH (infection, worsening kidney dz, extreme exercise)
high sickle concentration (dehydration)
drop off of other Hb types (age 3-4 months)
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- BWCT Flashcards on Protein Structure, created by Clare Wynne on 14/08/2016.
- Created by
- Clare Wynne · Aug 2016
- Updated
- Aug 15, 2016
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