756891
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| Type of RNA | -ve ss RNA |
| Virus Type | Enveloped- studded with NA or HA |
| Genome Segmentation | 8 segments |
| Proteins that Define Virus | HA and NA Variants |
| Effects of Upper Resp. Tract Infection | Destroys epithelial cells, loss of cilia function and cytokine storm caused by host immunity |
| Effects of Lower Resp. Tract Infection | Severe toxemia, replicates in alveoli and blocks air sacks |
| Secondary Infections | More common in Lower Resp. Tract Infections- Major Concern |
| M2 | Ion channel that carries the acidification of the vesicle into the virion to release DNA |
| HA Full Name | Haemaglutinin |
| HA Role | Trimer for virus attachment through Receptor Mediated Endocytosis |
| HA Inside the Vesicle | Changes conformation (unfolds) upon acidification |
| HA Interaction Inside Vesicle | Interacts with Sialic Acid when unfolded, then refolds, fusing the membranes together |
| Replication- Necessities | To make a complimentary +ve strand so -ve strand can be made |
| Genome Protein Transcription | +ve strand is used to make proteins |
| Role of Fragmentation | Allows for potential reassortment between 2 strains in the same cell |
| Influenza A Polymerase | Makes own, but is CAP stealing- takes 10-13 nt sequence from cellular mRNA |
| Location of Virion Assembly | Cell Envelope |
| NA (Full Name) | Neuraminidase |
| NA Role | Cleaves HA-Sialic Acid links and allows virion to exit cell |
| Drug Targets | M2 & NA |
| Vaccine Half Life | Generally useless by season after next |
| Whole Virus Vaccine | Good Immunity but side reactions |
| Split Vaccine | Detergent extracted whole virus |
| Subunit Vaccine | Detergent Extracted NA & HA from strain |
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