759030
Description
Flashcards by gina_evans0312, updated more than 1 year ago
|
Created by gina_evans0312
about 10 years ago
|
|
| Question | Answer |
| Age of Onset | Usually <15, but can be much earlier |
| Cause | Autoimmune Destruction of Beta cells (NO insulin is produced) |
| Key Symptoms | Tiredness, weight loss, Polyurea (Gluco & ketonuria) |
| Cause of most symptoms | Lack of insulin & no glucagon supression, so body is in starvation state despite excess blood glucose |
| Untreated Diabetes- Liver (Acetyl CoA) | Used in TCA to make energy for gluconeogenesis- excess is converted to ketone bodies and excreted into blood |
| Untreated Diabetes- Liver (Ketones) | Can lead to ketoacidosis of the blood |
| Untreated Diabetes- Muscle (GLUT4 Receptors) | Respond to lack of insulin by leaving cell membrane, so less glucose can enter |
| Untreated Diabetes- Muscle (Ketone Bodies/FAs) | Used to make Acetyl CoA for the TCA cycle and gluconeogenic energy |
| Untreated Diabetes- Muscle (Pyruvate) | Conversion to Acetyl CoA stops, instead converted back to glucose for use |
| Untreated Diabetes- Muscle (Effect of Ketone Bodies) | Prevents protein breakdown in muscle- needed for food search and so is counter productive |
| Untreated Diabetes- Adipose Tissue | Same as late phase starvation- TAGS broken down, FAs to muscle, glycerol to liver for breakdown |
| Untreated Diabetes- Plasma | Contains excess glucose and ketone bodies |
| Untreated Diabetes- Plasma (LPLs) | Insulin dependent, so non-functional = excess VLDLs and Chylomycrons in the blood |
| Untreated Diabetes- Urine | Excess glucose & ketone bodies are excreted in urine |
Want to create your own Flashcards for free with GoConqr? Learn more.