761938
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| Target | The A site on the 30s ribosome subunit |
| Entrance into Cells | Active transport into bacterial cells |
| Effect | Misreading of mRNA & malformed/premature proteins |
| Selective Toxicity | Bacterial ribosomes have A1408 & G1498 (other way around in humans) |
| Example | Gentamycin |
| Gentamycin- Spectrum (G+ve/-ve) | G+ve, some G-ve |
| Gentamycin- Half life | 2-4 hours |
| Gentamycin- Theraputic Window | Narrow |
| Gentamycin- Administration | Not orally - IV |
| Gentamycin- Metabolisis | Not metabolised |
| Gentamycin- Distribution | Extracellular |
| Gentamycin- Excretion | Glomerular filtration |
| Gentamycin- Adverse Effects (Ear) | Oxotoxicity- nerve cells die to cause hearing OR balance issues |
| Gentamycin- Adverse Effects (Kidney) | Nephrotoxicity |
| Gentamycin- Managing Levels | Done through assays to allow dose modification |
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