Flashcards
Histoplasma capsulatum
Cards in this deck (23)
- 1Mycelial FormUsed in low (<25) temps, found in the environment
- 2Yeast FormUsed at 37c, found in the tissue- more resistant to phagocytosis due to change in cell wall/virulence factors
- 3Pathogen TypePrimary
- 4TransmissionInhalation
- 5H.c variant capsulatum- LocationUSA
- 6H.c variant capsulatum- InfectionPulmonary and disseminated infection
- 7H.c variant duboisi- LocationCentral Africa
- 8H.c variant duboisi- InfectionSkin and bone infection
- 9SourceSoil with high N from droppings i.e. caves
- 10Infection- InhalationInhaled, and canidia is phagocytosed by macrophages
- 11Infection- ConversionConverts to yeast form and gains ability to multiply in macrophages
- 12Infection- Survival in Macrophages (Alpha-1,3-glycan)Alpha-1,3-glycan hides beta glycans that are detected by detectin-1 in macrophages
- 13Infection- Survival In Macrophages (Ca2+ Binding)Ca2+ binding protein helps survival in macrophages
- 14Infection- Survival In Macrophages (Lysosomes)Proteins present modulate lysosomal pH so phagocytosis doesn't occur
- 15Infection- MultiplicationThe yeast form thatn multiplies and spreads throughout the body
- 16Low Infection DoseAsymptomatic
- 17High Infection Dose- BothFlu like symptoms (13-17 days after exposure)
- 18High Infection Dose- FibrosisA rare complication
- 19High Infection Dose- DisseminationMore severe complication that occurs in children and the immunosuppressed
- 20High Infection Dose- capsulatumWeight loss, fatigue, enlarged liver
- 21High Infection Dose- gambienseSkin and bone abcesses
- 22TreatmentAzoles, other antifungals
- 23Diagnosis-Sample depends on symptoms, but direct microscopy and culture on 2 plates (one at 25, the other at 37)
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- Medical Microbiology (Mycology) Flashcards on Histoplasma capsulatum, created by gina_evans0312 on 18/04/2014.
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- gina_evans0312
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