767158
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| Mycelial Form | Used in low (<25) temps, found in the environment |
| Yeast Form | Used at 37c, found in the tissue- more resistant to phagocytosis due to change in cell wall/virulence factors |
| Pathogen Type | Primary |
| Transmission | Inhalation |
| H.c variant capsulatum- Location | USA |
| H.c variant capsulatum- Infection | Pulmonary and disseminated infection |
| H.c variant duboisi- Location | Central Africa |
| H.c variant duboisi- Infection | Skin and bone infection |
| Source | Soil with high N from droppings i.e. caves |
| Infection- Inhalation | Inhaled, and canidia is phagocytosed by macrophages |
| Infection- Conversion | Converts to yeast form and gains ability to multiply in macrophages |
| Infection- Survival in Macrophages (Alpha-1,3-glycan) | Alpha-1,3-glycan hides beta glycans that are detected by detectin-1 in macrophages |
| Infection- Survival In Macrophages (Ca2+ Binding) | Ca2+ binding protein helps survival in macrophages |
| Infection- Survival In Macrophages (Lysosomes) | Proteins present modulate lysosomal pH so phagocytosis doesn't occur |
| Infection- Multiplication | The yeast form thatn multiplies and spreads throughout the body |
| Low Infection Dose | Asymptomatic |
| High Infection Dose- Both | Flu like symptoms (13-17 days after exposure) |
| High Infection Dose- Fibrosis | A rare complication |
| High Infection Dose- Dissemination | More severe complication that occurs in children and the immunosuppressed |
| High Infection Dose- capsulatum | Weight loss, fatigue, enlarged liver |
| High Infection Dose- gambiense | Skin and bone abcesses |
| Treatment | Azoles, other antifungals |
| Diagnosis- | Sample depends on symptoms, but direct microscopy and culture on 2 plates (one at 25, the other at 37) |
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