Flashcards
Type 1 Interferons and NK Cells
Cards in this deck (28)
- 1Role of Type 1 Interferons and NK CellsMediate early innate immune response to viral infections
- 2Downside of T1I and NK CellsCan limit viral replication but can't stop it by themselves
- 3Type 1 Interferons- ProductionProduced by virally infected cells
- 4Type 1 Interferons- Role (Main)Induce resistance to viral infection in neighboring cells
- 5Type 1 Interferons- Role (mRNA)Induce proteins that break down mRNA
- 6Type 1 Interferons- Role (RNAase)Induce RNAases that prevent viral synthesis
- 7Type 1 Interferons- Role (Virion)Prevent release of virions from cells
- 8Type 1 Interferons- Role (MCH)Increases MHCI & II presentation to increase activation of CTLs and NK
- 9Missing Self- CauseSome viruses attempt to prevent immune activation by mutating/removing MHCI from the surface of cells
- 10Missing Self- Immune DefenseBody works around this by destroying any cells that don't express/epress mutated MHCI
- 11NK CellsNatural Killar cells aka large granular lymphocytes
- 12NK Cell- CD ExpressionNo TCR or BCR, CD3-, CD56+
- 13NK Cell- OriginArise from bone marrow, but need no thymal development
- 14NK Cell- Activation (ADCC)Antibody Dependent Cell Cytotoxicity
- 15NK Cell- ADCC (IgG Coated Cells)Infected cells will express surface antigens that IgG can bind to
- 16NK Cell- FcR aka Cd16A receptor for the Fc subunit of Igs that, when bound causes the release of perforin and granzymes, which kill the cell through apoptosis
- 17NK Cell- PerforinForms pores in the target cell through which the granzymes can enter
- 18NK Cell- Missing Self ModelWhere missing MHC causes the release of perforin and granzymes
- 19NK Cell- Missing Self Model (Inhibitory KIR/L49)Inhibitory receptors that, if bound to normal MHCI, prevents the NK cell from triggering apoptosis
- 20NK Cell- Missing Self Model (KIR Structure- ITIM)Immunoreceptor Try-Based Inhibitory Motif- found on inhibitor KIRs
- 21NK Cell- Missing Self Model (KIR Structure-ITAM)Immunoreceptor Tyr-Based Activating Receptor, found in Activating KIR
- 22NK Cell- Missing Self Model (Activation)Binding to cell where there is no MHCI, so there is no Inhibitory KIR/Ly49 binding, no inhibition and cell is apoptosed
- 23NK Cells- NCRsNatural cytotoxicity receptors that bind to viral HAs presented on cells
- 24NK Cells- Role (Cytokines)Release cytokines that induce adaptive immunity
- 25NK Cells- Role (Cytotoxic)Kill infected cells
- 26NK Cells- Role (Polarisation- IFNy)Promote polarisation of ThC1
- 27NK Cells- Role (IFNy/TNFalpha)Induce MHCI & II on normal cells
- 28NK Cells- Role (GMCF)Promote differentiation/maturation of monocyte,macrophages and dendritic cells
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- Year 2 Flashcards on Type 1 Interferons and NK Cells, created by gina_evans0312 on 18/04/2014.
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