767345
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| Role | To clear bacterial/viral/ parasitic infections |
| Activation- ICAM | Found on the host cell, part of the binding that allows the CTL to check the MHCI |
| Activation- LFA-1 | Receptor on the host cell that binds to ICAM and allows the CTL to check the MHCI |
| Activation- MHCI | Contains presented antigens- foreign antigens or a lack of MCH trigger cytotoxicity |
| Activation- Contact Dependent Ca2+ Dependent Cytotoxicity | Where granule release is mediated by an increase intracytoplasmic Ca2+ |
| Activation- Contact Dependent Ca2+ Dependent Cytotoxicity (Ca2+) | Needed to move granules to side of cell where interaction takes place |
| Activation- Contact Dependent Ca2+ Dependent Cytotoxicity (Perforin) | Polymerises on target cell and creates pores (requires Ca2+) |
| Activation- Contact Dependent Ca2+ Dependent Cytotoxicity (Granzymes) | Enter through pores and induce apoptsosis |
| Activation- Contact Dependent Ca2+ Dependent Cytotoxicity (Caspases) | Granzymes trigger a caspase cascade causing apoptosis |
| Activation- Fas-Fas Ligand Interaction (Fas Ligand) | Activated CTL induces Fas receptor on target cell |
| Activation- Fas-Fas Ligand Interaction (Fas Receptor) | CTL possesses Fas ligand to activate the caspase aptotic response |
| CTL Protection | Surface cathespin B protects cell from destruction by its own released granzymes |
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