Forming The Primary Follicle

Question	Answer
Location	Secondary lymphoid organs
Trapping B Cells- Naive B Cells	Pass through the lymph node during normal circulation- if they encounter their Ag, they become partially activated and trapped in the lymph node
Trapping T Cells- Dendritic Cells	Ag loaded dendritic cells migrate from the tissues to the paracortex of the lymph node
Trapping T Cells- Naive T-Cells	Naive T cells pass through the parcortex and are trapped by the presented Ag
Trapping T Cells- T-Cell Activation	In the presence of their Ag, that activate, proliferate, and become primed
Forming the Primary Follicle- Proliferating B & T Cells	B & T cells are now in close enough proximity for the changes of them both responding to the same Ag to be high
Forming the Primary Follicle- Th Dependent Activation	Through linked recognition, the B cell binds the Ag, and presents it to the T cell using MHCII
Forming the Primary Follicle- Secondary Signal	The primed T cell now provides the secondary signal for B cell activation, leading to the formation of a germinal centre

Resource summary

	Created by gina_evans0312 about 10 years ago