Affinity Maturation

Question	Answer
Germinal Centres	Centre of B cell alteration and proliferation
Affinity Maturation- Dark Zone	Part of germinal centre where affinity maturation occurs
Affinity Maturation- Centroblasts	Rapidly proliferating dark cells that are undergoing affinity maturation
Affinity Maturation- Somatic Hypermutation	Cells alter their BCR genes for the variable region in an attempt to inc. BCR affinity for the Ag
Affinity Maturation- Follicular Dendritic Cells's	Affinty Maturation is random, so Follicular DCs check the affinity of the new BCRs
Follicular DCs- Catch & Hold	FDCs aren't antigen presenting- they 'catch' and 'hold' out antigens for the new BCRs
Follicular DCs- Ag's	Bind Ag's/Compliment bound Ag/s and select cells with the highest affinity BCRs
Follicular DCs- Reduced Affinity BCRs	Don't bind and apoptose
Follicular DCs- Increased Affinity BCRs	Bind, and are saved from apoptosis by BCL-X expression
Follicular DC Iccosomes- Release	Small membrane derived immune complex coated particles are released
Follicular DC Iccosomes- Uptake by B cells	Iccosomes are taken up and presented to T cells
Follicular DC Iccosomes- T-Cell Binding	T cell-B cell B7-CD28 & CD40-CD40L binding ocurs, which allows the release of cytokines
Follicular DC Iccosomes- Cytokines	Only binding and cytokine release allows t-cell survival
B Cell Proliferation/Class Switching	B cells become plasma cells to produce Igs (which Ig depends on the microenvironment & the cytokine trigger)

Resource summary

	Created by gina_evans0312 about 10 years ago