Insulin Resistance

Description

Year 2 (Diabetes/MODY) Flashcards on Insulin Resistance, created by gina_evans0312 on 19/04/2014.
gina_evans0312
Flashcards by gina_evans0312, updated more than 1 year ago
gina_evans0312
Created by gina_evans0312 about 10 years ago
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Resource summary

Question Answer
What the fuck is it? A common pathological condition where the body fails to properly respond to insulin
Area of Effect Skeletal muscle
Associated With Obesity and chronically high blood FAs
Mechanism- White Adipose Tissue WAT acts as an endocrine organ, screting IL6, leptin, resistin and other adipokines that alter body responses to insulin
Proposed Mechanism of Action- PKC Adipokines P IRS1 on the serine residue, preventing P on the tyrosine residue, and it's role as a signal transducer to insulin
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