Cell Biology : SER, Golgi Apparatus and vesicle transport

Flashcards by savaniprachi, updated more than 1 year ago
Created by savaniprachi almost 7 years ago


Cell Biology Flashcards on Cell Biology : SER, Golgi Apparatus and vesicle transport, created by savaniprachi on 05/29/2014.

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The structure of the ER Dynamic network-continually breaking and reforming. Connected to the nuclear envelope. Forms hollow tubes and flattened sacs. Chambers are called cisternae. RER(ribosomes) and SER(no ribosomes)
Major functions of the ER 1. Synthesis 2. Storage 3. Transport 4. Detoxification
Functions of the SER 1. Phospholipid and cholesterol synthesis 2. Steroid hormone production 3. Synthesis and storage of glycerides 4. Synthesis and storage of glycogen 5. Important role as calcium store
Detoxification in the SER By the p450 cytochrome family: Break down of medications and toxins Involved in the synthesis of things such as steroid hormones Changes water insoluble drugs to soluble so they can be removed in urine
The structure of the Golgi Apparatus Flattened discs called cisternae has 5-6 cisternae near nucleus Communicates with ER and plasma membrane by vesicles
Functions of the Golgi Apparatus 1. Modifies and packages secretory proteins for release (exocytosis) 2. Renews and modifies the cell membrane 3. Delivery of material to other organelles
What is the site of Carbohydrate production? Golgi Apparatus
What do vesicle coats do? Aid in formation of the vesicle
What are the 3 types of coats and their involvement in specific transport? COPII - vesicles from ER to Golgi COPI - vesicles coming backwards from Golgi to ER Clathrin - endocytosis cell membrane to Golgi
What is the use of SNAREs? To help vesicles reach the correct targets
Where can you find the SNAREs? v-SNARE on the vesicle membrane t-SNARE on the target membrane
What are the 2 models for progression through the Golgi and how do they differ? Vesicular transport model - static where vesicles move from one cisternae to another Cisternae maturation model - dynamic where the cis may become trans
3 pathways from the trans-golgi network 1. Regulated secretory pathway - exocytosis 2. Constitutive secretory pathway - membrane proteins 3. Signal mediated diversion to lysosomes
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