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Hepatitis B

Description

Mind Map on Hepatitis B, created by yousaf alabrash on 01/03/2018.
yousaf alabrash
Mind Map by yousaf alabrash, updated more than 1 year ago
yousaf alabrash
Created by yousaf alabrash about 6 years ago
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Resource summary

Hepatitis B
  1. a viral infection of the liver
    1. anatomy of the liver
      1. hepatobiliary system
      2. physiology of the liver
        1. Blood reservoir
          1. recieves dual blood supply from portal vein and hepatic artery
          2. metabolism
            1. Glucose regulation - fatty acid synthesis - transamination
            2. detoxification
              1. removal of ammonia and drugs
              2. storage site
                1. Vitamen A-Vitamen B12-Iron
              3. Diagnosis and lab investigations
                1. serology
                2. signs and symptoms
                  1. mainly jaundice
                    1. types
                      1. Pre-hepatic
                        1. +++ RBC's destruction
                          1. +++ unconjugated bilirubin
                            1. casues
                              1. hemolytic anemia
                                1. thalassemia
                                  1. physiological jaundice
                                    1. dark urine - normal stool
                              2. hepatic
                                1. Liver disease
                                  1. ++ conjugated and unconjugated bilirubin
                                    1. causes
                                      1. hepatitis
                                        1. alcoholic liver disease
                                          1. liver cancer
                                          2. ++ AST-ALT /dark urine/ clay stool
                                      2. post-hepatic
                                        1. decrease flow of bile (obstruction)
                                          1. +++ conjugated bilirubin
                                            1. casues
                                              1. gallstones
                                                1. tumor head of pancreas
                                                  1. bile duct cancer
                                                  2. +++ ALP/dark urine/clay stool
                                        2. treatment
                                          1. antiviral drugs
                                            1. adefovir
                                              1. lamivudin
                                                1. entacavir
                                                  1. pegylated Interferon
                                                2. epidemiology
                                                  1. A
                                                    1. Developing countries with poor sanitary conditions and hygienic practices
                                                    2. B
                                                      1. Western Pacific Region and the WHO African Region
                                                      2. C
                                                        1. Eastern Mediterranean and European Regions
                                                        2. D
                                                          1. Mediterranean, Middle East, Pakistan, Central and Northern Asia, Japan
                                                          2. E
                                                            1. Resource-poor areas with frequent water contamination-Areas with safe drinking water supplies
                                                          3. General charecteristics of viruses
                                                            1. DNA
                                                              1. enveloped
                                                                1. HepaDNA
                                                                  1. Hepatitis B
                                                                    1. disease course
                                                                      1. Acute infection
                                                                        1. 90% resolution
                                                                          1. 1% fulminant hepatitis
                                                                            1. 9% becomes chronic
                                                                              1. resolution
                                                                                1. Asymptomatic carrier
                                                                                  1. chronic persistent hepatitis
                                                                                    1. chronic active hepatitis
                                                                          2. naked capsid
                                                                          3. RNA
                                                                            1. +
                                                                              1. enveloped
                                                                                1. Flavi
                                                                                  1. hep C
                                                                                2. naked capsid
                                                                                  1. pico
                                                                                    1. Hep A
                                                                                    2. Calici
                                                                                      1. Hep E
                                                                                  2. -
                                                                                    1. +/-
                                                                                      1. + via DNA
                                                                                    2. physiology of extrahepatic biliary system

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