muhammed's spleen is palpable

spleeen
1. histology
  1. stroma
    1. capsule
    2. trabeculae
    3. reticular network
  2. parenchyma
    1. white pulp
    2. red pulp
2. upper left quadrant of the abdomen
3. causes of splenomegaly
  1. complications
    1. anemia
    2. fullness
    3. spleen infarction
    4. frequent infection
  2. hemolytic anemia
  3. storage disease
    1. gaucher
    2. neimans pick
  4. splenic vein hypertension
    1. cirrhosis
  5. immunologicinflammatory disorders
    1. lupus
    2. amyloidosis
    3. sarcoidosis
  6. primary or metastic neoplasm
    1. leukemia
    2. cancer
    3. sarcoma
    4. lymphoma
epidemiology
investigation
1. cbc
  1. blood smear
2. biopsy
3. genetic tests
  1. karyotyping
  2. FISH
  3. PCR
WBC
1. disorders
  1. neoplastic
    1. lymphoid
      1. non- hodking's lymphoma
      2. hodgkin's lymphoma
      3. acute lymphoblastic leukemia
        age under 15
        tdt +
        more that 20% blast cells
      4. multiple myeloma
      5. chronic lymphocytic leukemia
        age to 6o+
        smudge cells
        proliferation of b cell. lymphoid cells
    2. myeloid
      1. chronic myeloproliferative disorders
        abl-bcr...... t(9:22)
        chronic myeloid leukemia
        slow progressiom
        age: 40-60
        risk factors
        ionizing radiation in high doses
        decreased LAP
        stages
        chronis
        accelerated
        blast
        treatment
        thyrosin kinase inhibitors
        chemotherapy
        stem cell
        JAK 2 mutation
        myelofibrosis
        polycythemia vera
        thrombocythemia
      2. acute myeloid leukemia
        age 15-609
        uer bodies
        more than 20% blasts
  2. non neoplastic
    1. neutrophilic leukocytosis
    2. eosinophilic leukocytosis
    3. basophilic leukocytosis
    4. monocytosis
    5. lymphocytosis
    6. reactive leukamoid reaction
      1. nap and lap positive
      2. 1500-100000 cells
breaking bad news
1. explain diagnosis and treatment
  1. face to face
    1. honesty
      1. arrange review
emotional/finantial coping
1. family and friends
  1. pt groups
2. caonsellors
3. cancer support nurses

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muhammed's spleen is palpable

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	Created by Ahmed salah about 6 years ago