15630189
Description
Mind Map by Katie Baugher, updated more than 1 year ago
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Created by Katie Baugher
over 5 years ago
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Glycans
- History
- Historical Roles
- Targeting signals
- Cancer progression
- Reaggregation of sponge cells
- Mediating proteins
- Energy
production and
metabolism
- Targeting signals
- Knowledge lag in the
study of function
- More rapidly
evolving
- Diverse and complex
- More rapidly
evolving
- Study of genetic alterations in
glycosylation in various organisms
- Discovery of genetic defect in I-cell disease
- Defect in PAPS formation
- deficiency of a glycosaminoglycan core
galactosyltransferase
- Knocking out class or subclass of glycan is
fatal, altering outer sugars gives living
organism with species-specific defects
- Discovery of genetic defect in I-cell disease
- Historical Roles
- Important examples in
vertebrates
- Sialic acid
- Sialoadhesins, or siglecs, are
lectin proteins that bind to it
- Modulates function of
certain proteins
- Sialoadhesins, or siglecs, are
lectin proteins that bind to it
- Mannose
- Intraorganismal target
signalling
- Intraorganismal target
signalling
- Mannose 6-phosphate
- Intraorganismal target
signalling
- Mediates transport of enzymes
to locations in the lysosome
- Intraorganismal target
signalling
- Heparin
- Interacts with
antithrombin
- Anticoagulant
effect
- Interacts with
antithrombin
- Sialic acid
- I-cell disease
- Genetic defect in this
disease proved the
biological importance of
the mannose 6
phosphate targeting
pathway
- Inhibits body's ability to
break down fats
- Causes low muscle tone,
developmental delay, and
some physical
abnormalities.
- Genetic defect in this
disease proved the
biological importance of
the mannose 6
phosphate targeting
pathway
- Glycoproteins
- Lectins
- Bound by glycans which
mediate their function
- Bound by glycans which
mediate their function
- Selectins
- Cell adhesion molecules
- Play a crucial role in
leukocyte trafficking
- Cell adhesion molecules
- Galectins
- Found in animals
- Facilitates crosslinking of
the ECM in animals
- Found in animals
- Other types of lectins
- R - signal targeting,
glycoprotein hormone
turnover
- L protein sorting
- P - protein sorting, signal
targeting, degradation
of glycoproteins
- C - cell adhesion,
glycoprotein clearance
and innate immunity
- R - signal targeting,
glycoprotein hormone
turnover
- Lectins
- Glycosylation
- Most common form
- Nucleocytoplasmic modification
- O-type glycosylation
- Nucleocytoplasmic modification
- Congenital disorders
- multisystem disorders caused by
enzymatic and genetic defects
- multisystem disorders caused by
enzymatic and genetic defects
- Most common form
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