T cells

T cells

Basics
1. Develop in Thymus
2. live 6 months to 20 + years
3. ~80% of recirculating pool
CD4/CD8
1. Promote adhesion and signal transduction for T cell activation
2. CD4 with beta2
3. CD8 with alpha3
TCR
1. TCR, CD3 complex, Zeta proteins
  1. TCR gamma delta
  2. TCR alpha beta
    1. Variable, constant, hinge region
    2. 3 CDRs (hypervariable regions)
      1. CDR3- most diverse
2. 50K+ and clonotypic
Other Co-Stimulatory
1. CD28
  1. always expressed
  2. part of Signal 2
  3. Ligand is B7 on proAPCs
2. CD2
  1. on mature T cells
  2. Ligand is CD58 (LFA-3)
    1. on ProAPCs or target cells
  3. T cell signal transducer
  4. Intercellular adhesion molecule
3. CD11aCD18
  1. Ligand CD54 (ICAM-1)
    1. on APCs and Target cells
  2. promotes binding of T cells to endothelial cells during T cell extravasation

Resource summary

	Created by Marjorie P over 9 years ago