Adaptive Immunity (ONLY Lecture 15 Part 2)

Adaptive Immunity (ONLY Lecture 15 Part 2)

1. Humoral Immunity

   • "Antibody-mediated"
   • B-cell based

2. Cellular Immunity

   • "Cell-mediated"
   • T-cell based

3. Types

   • Naturally acquired active
     • Getting sick
     • B memory cells
   • Nat. acq. passive
     • Transfer (mother's milk)
   • Artificially acq. active
     • Vaccination
   • Art. acq. passive
     • Antibodies from one host intro to another

4. Antigens

   • Epitopes
     • Reaction sites on antigens for specific antibody or T cell receptor
   • Affinity
     • Binding strength at just ONE site
   • Avidity
     • Overall antigen-binding at ALL sites

5. Major Histocompatibility Complex (MHC)

   • Genes code for self/nonself
   • In humans "Human Leukocyte Antigen" (HLA)
   • Three Classes
     • CLASS I
       • All types
       • Important for organ transplant
     • CLASS II
       • Antigen-presenting cells
       • Important for T-cell communications
         • Macrophages
         • Dendritic cells
         • B cells
     • CLASS III
       • Secreted proteins
       • Nonself/self recognition
   • Class I and II Structures
     • Heterodimers of alpha & beta subunits