Hereditary WBC Disorders

KevinShirley
Mind Map by , created almost 6 years ago

Mind Map on Hereditary WBC Disorders, created by KevinShirley on 11/20/2013.

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KevinShirley
Created by KevinShirley almost 6 years ago
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Hereditary WBC Disorders
1 May-Hegglin Anomaly
1.1 Associated Conditions

Annotations:

  • Abnormal bleeding may be present in some individuals.
1.1.1 thrombocytopenia
1.1.2 giant platelets
1.2 WBC's affected
1.2.1 neutrophils
1.3 appearance
1.3.1 Döhle-like bodies

Annotations:

  • Rod shaped inclusions at the edge of the cytoplasm. They are like Döhle bodies but larger.
1.4 prevalence
1.4.1 unknown
2 Alder-Reilly Anomaly
2.1 Associated Conditions
2.1.1 dwarfism
2.1.2 gargoylism
2.2 WBC's affected
2.2.1 All cell lines
2.2.1.1 hallmark feature
2.3 Appearance
2.3.1 coarse dark granulation
2.4 prevalence
2.4.1 rare
3 Pelger-Huet Anomaly
3.1 prevalence
3.1.1 common
3.2 associated conditions
3.2.1 leukemias
3.2.2 myleoproliferative disorders
3.2.3 severe infections
3.3 WBC's affected
3.3.1 segmented neutrophils
3.4 appearance
3.4.1 hyposegmentation of nucleus
3.4.1.1 heterozygotes
3.4.1.1.1 peanut-shaped
3.4.1.1.2 dumbbell-shaped
3.4.1.1.3 pince-nez-shaped
3.4.1.2 homozygotes
3.4.1.2.1 spherical non-lobed
4 Chediak-Higashi Syndrome
4.1 prevalence
4.1.1 rare
4.2 associated conditions
4.2.1 neutropenia
4.2.2 albinism
4.2.3 photophobia
4.2.4 recurrent staphylococcus infections
4.3 WBC's affected
4.3.1 neutrophils (mostly)
4.3.2 lymphocytes
4.3.3 monocytes
4.4 appearance
4.4.1 giant purple-gray granules