Cytokine receptors

Cytokine receptors

1. GHR

   • Jaks-stat-socs
   • inhibition
     • SOCS
     • PIAS
     • CIS

2. 3 groups

   • type I
     • also known as hematopoietin receptor
     • Share 3 common components: either gp130, bc, gc
     • Divided into 3 groups depending on which component they utilise (gp130, bc or yc)
   • Type II
     • also known as interferon receptors
   • another group responds to proinflammatory cytokines
   • both type I and II lack intrinsic protein kinase activity, they are structurally distinct

3. cytokine

   • polypeptide or low molecular weight protein involved in cell-to-cell signaling
   • Acts in paracrine or autocrine fashion through specific cellular receptors
   • Can be produced by cells of any tissue and act on many cells involved in immune and inflammatory response
   • act like hormones
   • eg interleukins, TGF-b and chemokines
   • Cytokines that use the same receptor component usually have overlapping effects in the immune system

4. signalling

   • ligand binds to dimer receptor or monomer receptors that dimerse
     • ligand binding recruits JAK
       • jak2 transphosophorylate each other
         • stat1 is recruited, phosphorylated and dimerised with another stat
           • stat dimer translocated to the nucleus and regulates transcription