4214835
Description
Mind Map by Nur Fadzliyana, updated more than 1 year ago
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Created by Nur Fadzliyana
over 8 years ago
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Hypersensitivity &
Autoimmune Disease
- Type 1
hypersensitivity or
allergy
- sensitization upon initial exposure:
allergen activation of CD4 T cell
differentation into Th2 cell
IL4,IL5,IL6,IL10 produce stimulate B cells
to produce IgE IgE bind to mast cells,
basophil, eosinophil
- Degranulation of sensitized cells:
cause anaphylaxis reaction(shock)
- sensitization upon initial exposure:
allergen activation of CD4 T cell
differentation into Th2 cell
IL4,IL5,IL6,IL10 produce stimulate B cells
to produce IgE IgE bind to mast cells,
basophil, eosinophil
- Type 11 hypersensivity
- 1) blood transfusion reaction
- 2) hemolytic disease
- 3) drug-induced by
hypersensitivity
- 1) blood transfusion reaction
- Type lll hypersensitivity (immune complex mediated) :
complex escape phagocytosis and complement
circulate trappedd in organ,joint, tissue trigger mast
cells to gedranulate damage the site
- 1) localised
immune complex
disease
- 2) systemic
immune
complex disease
- 1) localised
immune complex
disease
- Type IV hypersensitivity
(cell-mediated or delayed
type h/s)
- DTH reaction: ThI/Tdth cells cytokines released
migration inhibition factor prevent migration of
macrophages accumulation at site of infection
hypersensitivity response
- cause Autoimmune
disease
- DTH reaction: ThI/Tdth cells cytokines released
migration inhibition factor prevent migration of
macrophages accumulation at site of infection
hypersensitivity response
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