Hypersensitivity & Autoimmune Disease

Description

Abnormal function of immune system
Nur Fadzliyana
Mind Map by Nur Fadzliyana, updated more than 1 year ago
Nur Fadzliyana
Created by Nur Fadzliyana almost 9 years ago
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Resource summary

Hypersensitivity & Autoimmune Disease
  1. Type 1 hypersensitivity or allergy
    1. sensitization upon initial exposure: allergen activation of CD4 T cell differentation into Th2 cell IL4,IL5,IL6,IL10 produce stimulate B cells to produce IgE IgE bind to mast cells, basophil, eosinophil
      1. Degranulation of sensitized cells: cause anaphylaxis reaction(shock)
      2. Type 11 hypersensivity
        1. 1) blood transfusion reaction
          1. 2) hemolytic disease
            1. 3) drug-induced by hypersensitivity
            2. Type lll hypersensitivity (immune complex mediated) : complex escape phagocytosis and complement circulate trappedd in organ,joint, tissue trigger mast cells to gedranulate damage the site
              1. 1) localised immune complex disease
                1. 2) systemic immune complex disease
                2. Type IV hypersensitivity (cell-mediated or delayed type h/s)
                  1. DTH reaction: ThI/Tdth cells cytokines released migration inhibition factor prevent migration of macrophages accumulation at site of infection hypersensitivity response
                    1. cause Autoimmune disease
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