Immunology

Immunology

Disorder
1. hipersensitivity
2. cancer
3. autoimmunity
Signaling
1. cytokines
  1. anti-inflammatory
  2. inflammantory
2. chemokines
  1. lymph node localisation
  2. recruitment into the infection site
  3. homing of naive T and B cells
3. lipid mediators
  1. inflammatory
  2. anti-inflammatory
4. vasoactive amines
  1. histamine
5. co stimulation
  1. B cell to T cell
  2. antigen presenting cell to T cell
6. intracellular signalling
  1. initiation
  2. general principles
    1. 1) receptor activation
    2. 2) tyrosine kinase (TK) activation
    3. 3) transcription factors
  3. BCR,TCR and TLR
Adaptive
1. B cells
  1. B cell receptor
    1. co receptors
  2. B-cell development
    1. bone marrow
  3. antibody production : IgM, IgG, IgA, IgE
2. T cell subsets
  1. Treg
  2. CD4+
  3. CD8+
  4. gamma delta T cells
3. T cell receptor
  1. co receptors
    1. CD3
    2. zeta
Immune tissue
1. primary
  1. bone marrow
  2. fetal liver
  3. thymus
2. secondary
  1. lymph nodes
  2. spleen
  3. peyers patch
  4. peripheral tissue
  5. mucosa immune tissue
Fc receptor
1. B cells
2. phagocytes
3. mast cell
4. triggering
5. on complement
cell type associated cytokines
1. T cell
  1. CD4+
  2. CD8+
2. B cell
3. Innate
  1. Dendrite and macrophage
4. NK cells
Pathogens
1. parasites
2. fungal infection
3. viruses : 1) innate immune response 2) adaptive immune response 3) retroviruses
medical approach
1. vaccines
2. transplant
  1. tissue matching
  2. immunosuppression
Innate
1. cellular
  1. granulocyte
  2. monocytes
  3. innate-like lymphocytes
2. non cellular
  1. lysozyme
  2. defensins
  3. transferrin
  4. opsinisation and complement activating proteins

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	Created by Nur Fadzliyana over 8 years ago