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Neurotransmission and Second Messengers

Calcium
1. Release vesicles
2. Muscle contraction
3. Regulating blood flow
4. Platelet functioning
5. Activation of the clotting cascade
Metabolism of NE
1. Catechol-O-methyl transferase (COMT)
2. Monamine oxidase (MAO)
Noradrenergic receptors
1. Alpha 1: vascular smooth muscle contraction (vasoconstriction)
2. Alpha 2
  1. Inhibit NE release
  2. Inhibit NE-mediated vasoconstriction
3. Beta 1
  1. Increase heart rate
  2. Increased myocardial contractility
4. Beta 2
  1. Vasodilation
  2. Bronchodilation
Muscarinic receptors
1. M1
  1. Enteric nervous system
  2. Rest and digest
2. M2: decrease contractility and heart rate in the atria at the SA node
3. M3
  1. Increase bladder contraction
  2. Increase gut peristalsis
  3. Lacrimation or tearing
  4. Miosis
  5. Bronchoconstriction
Dopamine receptors
1. D1: relax renal vascular smooth muscle
2. D2: found in the brain
Histamine receptors
1. H1
  1. Allergy symptoms
  2. Pruritus
  3. Bronchoconstriction
2. H2: increase gastric acid secretion
ADH receptors
1. V1: increase vascular smooth muscle contraction
2. V2: increase reabsorption in collecting tubules of the kidney
G-protein second messengers
1. Alpha: Epi and NE
2. Beta: Epi and NE
3. M: ACh
4. D1, D2: dopamine
5. H1, H2: histamine
6. V1, V2: vasopressin

Neurotransmission and Second Messengers

	Created by snlogel over 10 years ago