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Drug Metabolism

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Notes from Doctors in Training
snlogel
Mind Map by snlogel, updated more than 1 year ago
snlogel
Created by snlogel over 10 years ago
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Resource summary

Drug Metabolism
  1. Phase I
    1. Reactions
      1. Reduction
        1. Oxidation
          1. Hydrolysis
          2. Metabolites
            1. Slightly polar
              1. Water soluble
                1. Active
              2. Phase II
                1. Reactions
                  1. Acetylation
                    1. Methylation
                      1. Sulfation
                        1. Glucuronidation
                        2. Metabolites
                          1. Very polar
                            1. Inactive
                          2. Disulfiram-like reaction
                            1. Metronidazole
                              1. Certain cephalosporins
                                1. Procarbazine
                                  1. 1st generation sulfonylureas
                                  2. Zero order kinetics
                                    1. Phenytoin
                                      1. Ethanol
                                        1. Aspirin
                                        2. TCAs
                                          1. Imipramine
                                            1. Clomipramine
                                              1. Amitriptyline
                                                1. Nortriptyline
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