Hemolytic Anemias

snlogel
Mind Map by , created over 5 years ago

Notes from Doctors in Training

25
1
0
Tags
snlogel
Created by snlogel over 5 years ago
Hepatitis
snlogel
T Cells
snlogel
Antidepressants
snlogel
A-level French Vocabulary
daniel.praecox
Biology B2.1
Jade Allatt
Cranial Nerves
snlogel
Platelets
snlogel
Psychosis and Antipsychotic Drugs
snlogel
Cardiac Embryology
snlogel
Liver Pathology
snlogel
Hemolytic Anemias
1 Intravascular hemolysis
1.1 Paroxysmal nocturnal hemoglobinuria
1.1.1 Missing CD55 and CD59
1.1.2 Positive Ham's test
1.2 Autoimmune hemolytic anemia
1.3 Mechanical destruction
2 Extravascular hemolysis
2.1 Hereditary spherocytosis
2.1.1 Ankyrin
2.1.2 Spectrin
2.1.3 Increased MCHC and RDW
2.1.4 Splenomegaly
2.1.5 Aplastic crises due to parvovirus B19
2.1.6 Osmotic fragility test
2.1.7 Splenectomy
2.2 G6PD deficiency
2.2.1 Sensitive to oxidative stress
2.2.1.1 Sulfa drugs
2.2.1.2 Fava beans
2.2.1.3 Infections
2.2.2 Heinz bodies
2.3 Pyruvate kinase deficiency
2.3.1 RBCs cannot generate ATP
2.3.2 Swelling and hemolysis of the red cells
2.4 Sickle cell disease
2.4.1 Low oxygen tension
2.4.2 Dehydration
2.4.3 Complications
2.4.3.1 Sequestration crisis
2.4.3.2 Autosplenectomy
2.4.3.3 Salmonella osteomyelitis
2.4.3.4 Aplastic criss due to parvovirus B19
2.4.3.5 Pain crises due to vasoocclusion
2.4.3.6 Renal papillary necrosis due to hypoxemia
2.4.4 Treatment
2.4.4.1 Hydroxyurea
2.4.4.2 Bone marrow transplantation
2.5 Hemoglobin C disease
2.5.1 Heterozygous: asymptomatic
2.5.2 Homozygous: mild hemolysis and splenomegaly
2.5.3 SC disease
3 Warm agglutinins (IgG antibodies)
3.1 Lupus
3.2 CLL
3.3 Drugs
4 Cold agglutinins (IgM antibodies)
4.1 CLL
4.2 Mycoplasma infections
4.3 Infectious mononucleosis

Media attachments