Pseudomembrane colitis (PMC)

Karo
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GI infections

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Karo
Created by Karo over 5 years ago
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Pseudomembrane colitis (PMC)

Annotations:

  • an acute, exudative colitis usually caused byClostridium difficile
1 can be caused by other bacteria than C. diff
1.1 Staphylococcus spp
1.2 enterotoxigenic Clostridium perfringens
1.3 Campylobacter spp.
1.4 Listeria spp.
1.5 Salmonella spp.
2 Symptoms
2.1 Typically, symptoms come on between 5 and 10 days after antibiotic therapy. Occasionally patients will not have had antibiotic exposure
2.2 Most patients become unwell during their course of antibiotics, but 25-40% may not do so for as many as 10 weeks afterwards
2.3 Most affected individuals experience watery diarrhoea (varies from self-limiting to severe and debilitating) ± blood-stained stools, abdominal cramps, fever (especially so in severe cases), rigors ± septicaemia.
2.4 Severe abdominal pain is uncommon but may mimic an acute abdomen.
2.5 Frank rectal bleeding suggests other causes (for example, inflammatory bowel disease).
3 lethal to elderly patients

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