Flashcards
The Penicillins
Flashcards do conjunto (32)
- 1which microorganisms that the commercial production of biosynthetic penicillins today depend on various strainsPenicillium notatum and Penicillium chrysogenum
- 2structure of penicillinBeta-lactam ring and thiazolidine ring (beta-lactam thiazolidine structure)
- 3gram-negative bacilli is resistant to ____?penicillins
- 4enzyme that inactivates penicillinspenicillinase
- 5two general types of the enzyme that inactivates penicillinsbeta-lactamases and acylases
- 6another name of Pen Gbenzylpenicillin
- 7it is an agent of choice for the tx of more different kinds of bacterial infection than any other antibioticPen G
- 8K, Ca and Na salts are inactivated by _______gastric juice
unless antacid/strong buffer (absorbed poorly from the intestinal tract)
large oral doses - 9amine sale of penicillin G was made with _______procaine
- 10preparation of Pen G Procainefrom Pen G Na by treatment with Procaine HCl
- 11it is a salt of diamine composition of the diaminePenicillin G Benzathine
2 moles of penicilline are available from each molecule (very insoluble in water = great stability and prolonged effect) - 12another name of Pen Vphenoxymethylpenicillin
- 13Pen V is resistant to hydrolysis by ________________ and its ability to produce uniform concentration in ____________gastric juice; blood
(when administered orally) - 14Methicillin sodium is particularly resistant to inactivation by the ___________ found in _________ and somewhat more resistant than __________ to penicillinase from ________________.penicillinase; staphylococci; Pen G; Bacillus cereus
- 15it is used in the treatment of staphylococcal infections caused by strains resistant to other penicillinsmethicillin sodium
- 16Explain: resistant to inactivation by the penicillinasesince penicillinase inactivates the penicillin, this now means that the bacteria is susceptible to the drug because it resists the inactivation by the penicillinase
- 17it is highly resistant to inactivation by penicillinaseoxacillin sodium
- 18chlorine atom ortho to the position of attachment of the phenyl ring to the isozaxole ring enhances the activity of __________________ ____________cloxacillin sodium
enhances its oral absorption - 19dicloxacin sodiumits medicinal properties and use are similar to those of cloxacillin sodium
- 20nafcillin is stable enough in _______ to perming its use by _______ administrationacid; oral
- 21another semisynthetic penicillin that resulted from the search for penicillinase-resistant compoundsnafcillin soidum
- 22Nafcillin sodium may be used in infections caused solely by ___________ __________ ______________ or when _______________ are present also.penicillin G-resistant staphylococci; streptococci
- 23its antibacterial spectrum is broader than that of penicillin GAmpicillin
- 24It is particularly useful for the treat- ment of acute urinary tract infections caused by _____ or ___________ and is the agent of choice against _________ infections.E. coli; Proteus mirabilis; Haemophilus influenzae
- 25ampicillin + ________ = tx for gonorrheaprobenecid
- 26It is a prodrug of ampicillin with no antibacterial activity hydrolyzed rapidly by _____Bacampicillin HCl
esterases - 27it has largely replaced ampicillin for the treatment of certain _____ and__________ for which oral administration is desirableAmoxicillin
systemic; UTI - 28it has a broad range of antimicrobial activity, broader than any other known penicillinCarbencillin Disodium, Sterile
- 29provides an orally active alternative for the treatment of _________ and _______ caused by Pseudomonas spp., indole-positive Proteus spp., and se- lected species of Gram-negative bacilli.Indanyl carbenicillin; carbenicillin- sensitive systemic ; UTI
- 30advantages of ticarcillin(a) slightly better pharmacokinetic properties, including higher serum levels and a longer duration of action; and (b) greater in vitro potency against several species of Gram- negative bacilli, most notably P. aeruginosa and Bacteroides fragilis.
- 31an acylureidopenicillinMezlocillin Sodium, Sterile
(See p 273) - 32It is more active than mezlocillin against susceptible strains of Gram-negative aerobic bacilli, such as Serratia marcescens, Proteus, Enterobacter, Citrobacter spp., and P . aeruginosa ex- tended-spectrum acylureidopenicillinsPiperacillin Sodium, Sterile
see p 274
Informações
- Descrição
- FlashCards sobre The Penicillins, criado por aaudreylynnn em 10-09-2014.
- Criado por
- aaudreylynnn
- Visualizações
- 90
- Tags
- Avaliação