Flashcards
STD
Flashcards do conjunto (47)
- 1MOMPMOM P has chlamydia
- 2#1 cause of blindness (Be specific)Chlamydia trachomatis
Serovars A, B, C - 3Fitz-Hugh-Curtis is associated with...C. trachomatis & N. gonorrhoeae
- 4What is Fitz-Hugh-Curtis syndrome?bacteria escaping thru fallopian tube, causing perihepatitis
- 5Reiter Syndromereactive arthritis
80% of men with reactive arthritis have C. trachomatis - 6Lymphogranuloma Venerum cause (be specific)C. trachomatis Serovars L1-L3
- 7C. trachomatis is neonatesneonatal conjunctivitis
purulent discharge, eyelid swelling, conjunctival scarring
may develop c. trachomatis pneumonia - 8Staccato cough is associated with...infant pneumonia (2-3 weeks of age) due to chlamydia trachomatis
- 9C. trachomatis DiagnosisNAAT
Antigen Detection - MOMP or LPS - 10C. trachomatis TreatmentFor uncomplicated..
Azithromycin (1000 mg) x1 or
Doxycycline x7 days
Probably should give ceftriaxone in case of gonorrhae - 11N. gonorrhoeae microAerobic, gram negative cocci
Oxidase positive
Can't grow on blood
Grows on chocolate with 5% CO2
"When you're GONorrhoeae, I need air, and I have to eat a lot of chocolate. & I can't help but hyperventilate" - 12N. gonorrhoeae Virulence FactorsPPOL
Pili - to attach to nonciliated epithelium
PorB - prevents phagolysosome fusion
Opa - mediates attachment to host cells
LOS - Lipd A & core oligo (lacks O-antigen)
"Opaaaaa! I attached to the host" (insert Greek accent) - 13Clinical Man. of Clap in menSymptomatic acute urethritis
- 14Clinical Man. of Clap in WomenMost asymptomatic
Cervicitis, Urethritis, PID, Fitz-Hugh - 15Prophylactic ointment for neonates to prevent opthalmia neonatriumerythromycin ointment
- 16N. gonorrhoeae DiagnosisNAAT
Culture for susceptibility
Microscopy - PMN with IC gram neg diplococci - 17N. gonorrhoeae TreatmentCeftriaxone
Cover Co-infection with Azithromycin - 18Treponoma pallidum MicroSpirochete w/ polar flagella at each end
Need to use darkfield microscopy - 19Syphilis Phase 1Site of infection (chancre)
painless ulcer - 20Syphilis Phase 2Disseminated disease
Rash
Lymphadenopathy
Condyloma latum (raised gray lesions in mucous membranes)
Neurosyphilis (asymptomatic) - 21Syphilis Late PhaseInvolvement of multiple sites
Neurosyphilis
Aortitis
Gummas
Such a NAG - 22Argyll-Robertson pupilAccomodation, but no pupil reflex to light
Syphilis
Due to Tabes dorsalis - 23Congenital syphilisHepatomegaly and jaundice
Snuffles
Lymphadenopathy
Hutchinson Teeth
Saber shins - 24List the nontreponemal testsAntibodies to caridolipins
VDRL
RPR - 25List the Treponemal TestsAntibodies to specific treponemal antigens
FTA-ABS (Ab-Absorption)
TP-PA (particle agglutination)
TP-EIA - 26Syphilis TreatmentPenicillin
"Syft through the box of Pencils"
Alternatives: Doxy or Azith (like in chlamydia)
Only penicillin can be used for neurosyph!! - 27Jarish-Herxheimer ReactionFebrile Rxn w. headache, myalgias after taking penicillin
Syphilis - 28Chancroid microaka Haemophilus ducreyi
gram neg coccobacilli
Can grow on specialized agar (Hb, Abx) - 29Chancroid Clinical Man.5-10d incubation
Tender erythematous papule-->pustule-->ulcer
Inguinal lymphadenopathy - 30Chancroid DiagnosisCulture ulcer base
Requires specialized media - 31Chancroid TreatmentMacrolide or Ceftriaxone (just 1 does of either)
People Chanc (shank) people because they macroLIDE or tried to kill them with an cefetriAXone) - 32Granuloma inguinaleaka Klebsiella granulomatis
aka Donovanosis
South America, Caribbean, India, Australia - 33Granuloma inguinale Clinical Man.Subcutaneious genital nodules or inguinal area
Typically lacks inguinal lymphadenopathy - 34Granuloma inguinale DiagnosisTissue sample for Donovan bodies to see bacteria in phagocytes
- 35Granuloma inguinale TreatmentAzithromycin
Granny gives no aZITHromycin about you. She does what she wants, shows up and gives you a beefy-red ulcer. - 36HSV PathogeneisisBinds to heparan sulate
Replicates in epithelial cells and causes lytic infection at site
Establishes latency in neurons
Blocks TAP protein and goes cell2cell - 37Oral herpesHSV-1 or 2
ginviovostomatitis - oral lesions
can have pharyngitis - 38Encephalitis with HSVinvolves temporal lobe with RBCs in CSF
any age can develop this
fever, headache, seizures, focal neurologic signs - 39HSV DiagnosisPCR
Viral culture of vesicular fluid
DFA
Serology (for primary)
Biopsy (3 Ms- margination, molding, multinucleation) - 40HSV Treatmentnucleoside analogues that inhibit viral DNA polymerase
Acyclovir, Valacyclovir, Penciclovir, Famciclovir
*Substrate for DNA polymerase - 41HPV micronaked dsDNA
- 42Cutaneous Warts TreatmentImiquimod or interferone
Topical Cidofovir - 43Trichomoniasis TreatmentMetronidazole
Get that TRICHomoniasis off the Metro - 44pHs with vulvovaginitisTrichomoniasis - >4.5
Candida - pH normal (4 - 4.5) - 45Candida Vulvovaginitis TreatmentNystatin or azoles
Candy is Nasty and an Az-hole - 46Bacterial Vaginosis TreatmentMetronidazole
Get the girl with the "fishy odor" off the Metro (along with that TRICH) - 47—