Flashcards
Antibiotics Chart
Cards in this deck (75)
- 1Penicillin Mechanism of ActionCell wall disruption
- 2PCN ExcretionRenal
- 3PCN Resistance Patterns-Beta-lactamase
-altered binding site
-Reduced entry - 4PCN is DOC for..Syphilis
Streptococci - 5Ampicillin is DOC for...Enterococcus
Listeria - 6PCN adverse reactionsRash
GI distress
Seizures
Bone marrow suppression - 7CEPH MoACell wall disruption
- 8CEPH Resistance PatternsBeta-lactamase
Altered binding site
Reduced entry - 9Ceftriaxone is DOC for..Bacterial meningitis
- 10Cefepime is DOC for...Pseudomonas Aeruginosa
- 11Ceftaroline is an option for...MRSA
- 12CEPH Adverse Reactionssimilar to PCN (rash, GI distress, seizures, bone marrow suppression)
Cross allergy with PCN - 13Carbapenems MoACell wall disruption
- 14CARBAP ExcretionRenal
- 15CARBAP Resistance PatternsCarbapenemase
Altered binding site
Reduced entry - 16CARBAP Adverse Reactionssimilar to PCN (rash, bone marrow suppression, seizures, GI distress)
_Cross allergy with PSN
_Seizures
_Superinfections - 17Monobactam is aka...Aztreonam
- 18Monobactam MoACell wall disruption
- 19Monobactam ExcretionRenal
- 20Monobactam Resistance PatternAltered binding site
Enzymatic degradation - 21Monobactam Adverse RxnsSimilar to PCN (GI distress, seizures, bone marrow suppression, rash)
No cross allergy to PCN - 22Aminoglycosides MoAProtein synthesis 30s
- 23AMINOG excretionRenal
- 24AMINOG Resistance PatternReduced entry
Enzymatic degradation - 25AMINOG Adverse RxnsNephrotoxicity
Ototoxicity
Neuromuscular blockade - 26Tetracycline MoAProtein synthesis 30s
- 27Tetracycline ExcretionMostly renal
- 28Tetracycline Resistance PatternReduced entry
Active efflux - 29Tetracycline is DOC for...Chlamydia
Arthropod-borne diseases - 30Tetracycline Adverse RxnsGI distress
Rash
Photosensitivity
Depressed bone growth
Discolored teeth - 31Chloramphenicol MoAProtein Synthesis 50s
- 32Chloramphenicol ExcretionRenal
- 33Chlorampenicol Resistance PatternReduced entry
Enzymatic degradation - 34ChloramphenicolAplastic anemia
"Gray Baby Syndrome"
Optic Neuritis - 35Macrolides MoA50s
- 36Macrolides ExcretionBiliary
- 37Macrolides Resistance PatternAltered binding site
Reduced entry - 38Macrolides is DOC for...Legionella
Mycoplasma
Diphtheria
Pertussis - 39Macrolides Adverse RxnGI distress
rash
gout exacerbation - 40Quinupristin-dalfopristin MoA50s
- 41Quinupristin-dalfopristin ExcretionBiliary
- 42Quinupristin-dalfopristin Adverse Rxnsdrug interactions
hyperbilirubinemia
arthralgias/myalgias
vein sclerosis - 43Linezolid MoAfMet-tRNA
- 44Linezolid ExcretionMostly biliary
- 45Linezolid is DOC forVRE
MRSA penumonia - 46Linezolid Adverse RxnsMAO inhibitor,
enhances
adrenergic and serotonergic meds,
GI distress,
thrombocytopenia - 47Daptomycin MoAdisruption
of cell
membrane
potential - 48Daptomycin ExcretionMostly renal
- 49Daptomycin Resistance Pattern? membrane
potential
dissipation - 50Daptomycin is DOC for..MRSA,
VRE other Gram + organisms found in skin and soft tissue infxns - 51Daptomycin Adverse RxnsMuscle pain and weakness
elevated CPK levels - 52Trimethoprim-sulfamethoxazole MoAFolate synthesis
- 53Trimethoprim-sulfamethoxazole ExcretionRenal
- 54Trimethoprim-sulfamethoxazole Resistance PatternAltered binding site
Reduced entry - 55Trimethoprim-sulfamethoxazole is DOC for...Pneumocystis carinii
Stenotophomonas maltophilia
Nocardia - 56TMP-SMC Adverse Rxnsrash,
GI distress,
hepatic dysfunction,
renal dysfunction,
bone marrow suppression - 57Quinolones MoADNA Synthesis
- 58Quinolones ExcretionRenal
Biliary - 59QuinolonesAltered binding site
Active efflux - 60Quinolones Adverse Rxnsrash,
GI distress,
drug interactions,
bound by metals and cations - 61Vancomycin MoACell wall disruption
- 62Vanco ExcretionRenal
- 63Vanco Resistance PatternAltered binding site
- 64Vanco is DOC for...PRSP meningitis
? MR Staph - 65Vano Adverse Rxnsototoxicity
? nephrotoxicity
vein sclerosis
rash/Redman
Syndrome - 66Clindamycin MoA50s
- 67Clinda ExcretionBiliary
- 68Clinda Resistance PatternAltered binding site
- 69Clinda Adverse Rxnsrash,
GI distress
Pseudomembranous
colitis - 70Metronidazole MoADNA synthesis
- 71Metro ExcretionBiliary
- 72Metro is DOC for...anaerobic bacteria
- 73Metro Adverse Rxnsmetallic taste,
Disulfiram-like reaction,
peripheral neuropathy,
pancreatitis - 74What antibiotics are excreted by the biliary system?Macrolides
Quinopristin-dalfopristin
Linezolid (mostly)
Quinolones (and renal)
Clindamycin
Metronidazole - 75What antibiotics are excreted by the renal system?Penicillin
Cephalosporins (mostly)
Carbapenems
Monobactam
Aminoglycosides
Tetracyclime (mostly)
Chloramphenicol
Daptomycin (mostly)
TMP-SMX
Quinolones (and biliary)
Vancomycin