Flashcards
Fundamentals Tutorial Week 2
Flashcards do conjunto (20)
- 1Concerning drug receptor interaction, the constant Kd refers to:Drug concentration required to occupy 50% of receptors
- 2G protein-coupled receptors are characterised by:7 transmembrane domains
- 3Which of these is NOT an effect that follows receptor activation? a. Increase in intracellular cAMP levels b. Increase in intracellular calcium levels c. Increase in intracellular IP3 levels d. Increase in intracellular ATP levelsD) Increase in intracellular ATP levels
- 4Which statement is TRUE regarding competitive receptor antagonism? a. Competitive antagonism is based on reversible antagonist binding at the receptor active site. b. With competitive antagonism, maximal drug effect is lower c. With competitive inhibition, maximum drug effect cannot be obtained, even at high agonist concentrations d. With competitive inhibition, the dose-effects curve is shifted to the leftCompetitive antagonism is based on reversible antagonist binding at the receptor active site.
- 5How is GABA channel changing nerve membrane polarity?It increases polarisation
- 6Which drug exerts much of its effects through intracellular receptors? Select one: a. Phenytoin b. Diazepam c. Fluticasone d. FlumazenilFluticasone ( a steroid)
- 7Which of the following statements is NOT TRUE regarding the binding site of a receptor? a. The binding site is normally a hollow or cleft in the surface of a receptor b. The binding site is normally hydrophobic in nature c. Ligands fit into binding sites and bind to the functional groups within it d. Receptor binding site contains amino acids which are important to the binding processThe binding site is normally hydrophobic in nature
- 8Which of the following reactions is catalyzed by a protein kinase? a. Phosphorylation of alcohol groups in protein substrates b. Hydrolysis of phosphate groups in protein substrates c. Phosphorylation of alcohol groups in carbohydrates d. Hydrolysis of phosphate groups in ATP and GTPPhosphorylation of alcohol groups in protein substrates
- 9What determines the degree of movement of a drug between body compartments?Charge of the drug &
pH within the compartment &
Size of the drug molecule - 10describe drug minimal effective concentration (MEC)?The minimal drug plasma concentration to produce effect
- 11What indicates amount of a drug absorbed per amount administered?bioavailability
- 12Bioavailability is a percentage of administered drug that reaches the systemic circulation via a given route as compared to which route?IV
- 13Given a graph of plasma drug concentration versus time, what part of the graph would be used to calculate bioavailability?AUC
- 14Drug biotransformation Phase I makes drugs ____ polar for metabolism and Phase II makes drugs ____ polar for excretionDrug biotransformation Phase I makes drugs MORE polar for metabolism and Phase II makes
drugs MORE polar for excretion - 15Which of the following is NOT a liver Phase II substrate? a. Glucuronic acid b. Sulphate c. Acetate d. Alcohol Calcohol
- 16Which of the following is the equilibrium dissociation constant, where the concentration of free drug is at half-maximal binding?Kd
- 17Which of the following is increased in intracellular concentration due to signalling molecule IP3? Select one: a. K+ b. Ca++ c. Cl- d. Na+Ca++
- 18Which direction would a PARTIAL agonist shift the dose-response curve when compared to a full agonist?DOWN
- 19Which of the following is NOT an action of the body on a drug? a. Absorption b. Distribution c. Metabolism d. Drug side effectsD- drug side effects
- 20What is the correct order of bond strength, from strongest to weakest?Covalent > Ionic > Hydrogen >
Van der Waals
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- pharmacology (Tutorial Questions) FlashCards sobre Fundamentals Tutorial Week 2, criado por Amelia Claire em 27-03-2017.
- Criado por
- Amelia Claire
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