Diabetes

Diabetes

lack of insulin

increased hepatic output of glucos

increased catabolism of proteins in muscle tissue

increased lipolysis and release of fatty acids from adipose tissue

acute metabolic abnormalities

reduction in glucose use

increase in hepatic glucose production

Hyperglycemia

glycosuria

osmotic diuresis

polyuria

polydipsia

biguanides

thiazolidinediones

⬆peripheral glucose uptake

glucose absorption by the intestines

alfa glucosidase inhibitors

sulfonylureas

insuline realease

GLP1a

DPP41

inhibit the inactivation of GLP-1, prolonging its effects

renal reabsorption of glucose

iSGLT2

insulin

inactivate hepatic fosfolipase