HIV Progression Flow Chart

1) Viremia

-large viral load

2) Antigen uptake by APC's

-produce INF-gamma (antiviral response)

3) MHC Class I to activate CD8+ T cytotoxic cells

4) Clinical Latency

-CD4+ T helper cells deplete over time

-these cells mediate everything SO w/o them there are negative downstream effects

5) AIDS

-now have a weakened immune system

-usually expire from some other microbial pathogen/infection (unrelated to AIDS)

PROGRESSION OF HIV

-as an example of 2° immunodeficiencies