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8644439
Attachment of Ub to Target Protein
Descrição
Ubiquitin mechanism for protein targeting
Sem etiquetas
ubiquitin
amp
atp hydrolysis
e1
thioester
transthiolation
e2
e3
cys
lys-48
biology
biochemistry
Fluxograma por
Chinazor Okeke
, atualizado more than 1 year ago
Mais
Menos
Criado por
Chinazor Okeke
aproximadamente 7 anos atrás
10
0
0
Resumo de Recurso
Nós do fluxograma
1. -NH of Lys residue on protein is covalently attached to the COO- terminus of Ub
2. Another Ub attaches to the Lys 48 -NH of the first Ub
3. Repeat Steps 2 twice until you get four covalently attached Ubs
4 Ub's = the DEATH MARK
1. E1 activates the Ub by adenylating -COO with AMP (hydrolysis of ATP into AMP and PPi)
2. E1 transfers Ub onto its Cys residue to form a high E thioester bond, thereby removing AMP
3. A transthiolation reaction transfers an activated Ub from E1 to E2
E2 is now bonded to Ub via a thioester bond
4. E3 recognizes and associates with both the E2-Ub complex and the target protein
E1 = Ub activating enzyme
E2 = Ub conjugating enzyme
5. E3 catalyzes the transfer of Ub onto amino groups on specific Lys on the target protein
6. W/ E3 still bound to the target protein, repeat steps 1-5 until 3 more Ubs are attached
E3 = scaffold b/c it recognizes both target protein and E2-Ub complex
E3 = Ub ligating enzyme
Ubiquitin Targeting and Mechanism
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