323913
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
mais de 10 anos atrás
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Questão 1
Questão
What is so special about cGMPPK?
Responda
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It's anti-parallel
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The subunits of the dimer can swap roles of damage occurs
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It's only found in cardiac cells
Questão 2
Questão
How many cGMP bind per monomer?
Responda
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2
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4
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6
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1
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3
Questão 3
Questão
Which order do the subunits go in (from N to C terminus)
A= Dimerisation Domain
B- Catalytic Domain
C= Autoinhibitory Hinge Region
D= cGMP binding sites 1 & 2
Responda
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A-C-D-B
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A-B-D-C
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C-A-D-B
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C-D-A-B
Questão 4
Questão
What is the purpose of the autoinhibitory hinge region?
Responda
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Acts as a pseudosubstrate
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Causes inhibition after a certain amount of activity
Questão 5
Questão
What motif does cGMP Stimulated Protein Kinase Phosphorylate?
Responda
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Arg-Ser-X-Arg
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Arg-Thr-X-Arg
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Arg-Arg-X-Ser
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Arg-Arg-X-Thr
Questão 6
Questão
What is the role of this protein?
Responda
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The activation of cGMP dependent ion channels
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Activates cGMP dependent phosphodiesterases
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The activation of cGMP dependent proteins
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Inhibits cGMP dependent phosphodiesterases
Questão 7
Questão
What is required for NO to be synthesized?
Responda
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NO synthase
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FMD/FAD
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O2
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NADP
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NADPH
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FMD
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Tetrahydrobiopterin
Questão 8
Questão
Which of the following stimulate NO production?
A- AcH
B- Bradylunin
C- Nicotine
D- Thrombin
E- Cl-
F- Ca2+
Responda
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A, B, D, F
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A, D, E, F
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B, C, D, F
Questão 9
Questão
Which system is NO part of?
Responda
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Paracrine
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Juxtracrine
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Autocrine
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Endocrine
Questão 10
Questão
NO is synthase a monomer- True or False?
Responda
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True
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False
Questão 11
Questão
How many types of NO synthase are there?
Responda
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Constitutive
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Inducible
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Constitutive & Inudcible
Questão 12
Questão
Why is NO produced by iNOS (Immune NO Synthase)
Responda
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It kills of pathogens
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It's used to signal immune cells
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It's used to bind and immobalise pathogens
Questão 13
Questão
NO Synthase produces a few mmol of NO over a minute- True or False?
Responda
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True
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False- its pmol over a minute
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False, it's micromol in a few seconds
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False, its pmol over a few seconds
Questão 14
Questão
NO Synthase contains the following, but in which order?
A-NADPH binding site
B-Calmodulin Binding Site
C-FMN centre
D- FAD centre
E-Haeme group
F- Arg, O2 and Tetrahydropterin (Active site)
Responda
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E-F-B-C-D-A
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A-D-B-C-F-E
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E-F-A-C-D-B
Questão 15
Questão
Why are vascular endothelial cells equipped to cause vasodilation?
Responda
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It allows them to reduce blood pressure according to need
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It allows them to increase blood flow to wounded areas
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It prevents damage to veins under high pressure
Questão 16
Questão
Which neurotransmitter effects which cells?
A- Ach
B-Vasopressin
Responda
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Vascular Endothelial-A Skeletal Muscle-B
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Vascular Endothelial- A&B Skeletal Muscle-A
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Vascular Endothelial- A Skeletal Muscle-A&B
Questão 17
Questão
What is the role of nitroglycerin?
Responda
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An explosive
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It liberates NO from tissues
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Causes an increase in NO synthesis
Questão 18
Questão
What is the role of viagra?
Responda
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Inhibits phosphodiesterases
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Prevents cGMP breakdown
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Prolongs NO production
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