323865
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| [3,5-cGMP] is | 10-100x lower than cAMP |
| When is 3,5-cGMP produced? | In response to drugs/toxins |
| Guanylate cyclase is a homo/hetero-dimer/monomer/multimer | Homodimer |
| Where is G.C's dimerisation domain found? | Inside the cell |
| Where is G.C's ligand recognition site? | Extracellular |
| How many amino acids are different between catalytic sites 1 & 2? | 2 |
| How many types of guanylate cyclase are there? | 8- only 3 have known ligands |
| What are the ligands for G.C's Types A & B? | Atrial Natiuretic Peptides |
| What are Atrial Natiuretic Peptides? | Produced by the heart to control blood pressure, diuresis & natriuresis |
| What is the ligand for G.C Type C? | Guanylin & uroguanylin |
| Where are guanylin/urogaunylin produced? | The gastro-intestinal tract |
| What is type C used to regulate? | Na+, Cl- and water transport |
| Which type of G.C does E.Coli Stable Enterotoxin bind to? | Type C |
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