329387
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| When T.K is phosphorylated, which subunit of PI-3-Kinase binds first? | P85 |
| What allows the regulatory subunit to bind? | The Sh2 domain |
| Name the catalytic subunit of PI-3-Kinase | p110 |
| When PI-3-Kinase is complete, what binds? | Activated RAS |
| Role 1 of PI-3-Kinase | Phosphorylation if PIP2 to PIP3 |
| Part of PDK1 that allows PIP3 interaction | Plectstrin homology domain |
| Where does PDK1 activation occur? | The membrane |
| What membrane molecule does PKB bind to? | Phosphatidynositol-3,4-bisphosphate |
| Inactive PKB Structure | Has a pH domain and an activation lip hiding the kinase |
| Part of PKB that binds to PIP2 | pH domain |
| PKB binds to PIP2 | Causing partial activation |
| Partial Activation caused by | PDK1 phosphorylating its activation lip |
| Full activation caused by | PDK2 phosphorylating its C terminus |
| PKB moves GLUT4 to membrane (T/F) | True |
| PKB causes Glycogen breakdown (T/F) | False- it causes glycogen synthesis |
| PKB increases protein synthesis (T/F) | True |
| PKB phosphorylates Glycogen Synthase Kinase (T/F) | True- this prevents the deactivation of glycogen synthase |
| PDK1 directly phosphorylates PKB (T/F) | True |
| What allows the different proteins to bind to T.K? | The aa surrounding the tyrosine kinase |
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