Flashcards
PKB Activation Through RAS
Cards in this deck (19)
- 1When T.K is phosphorylated, which subunit of PI-3-Kinase binds first?P85
- 2What allows the regulatory subunit to bind?The Sh2 domain
- 3Name the catalytic subunit of PI-3-Kinasep110
- 4When PI-3-Kinase is complete, what binds?Activated RAS
- 5Role 1 of PI-3-KinasePhosphorylation if PIP2 to PIP3
- 6Part of PDK1 that allows PIP3 interactionPlectstrin homology domain
- 7Where does PDK1 activation occur?The membrane
- 8What membrane molecule does PKB bind to?Phosphatidynositol-3,4-bisphosphate
- 9Inactive PKB StructureHas a pH domain and an activation lip hiding the kinase
- 10Part of PKB that binds to PIP2pH domain
- 11PKB binds to PIP2Causing partial activation
- 12Partial Activation caused byPDK1 phosphorylating its activation lip
- 13Full activation caused byPDK2 phosphorylating its C terminus
- 14PKB moves GLUT4 to membrane (T/F)True
- 15PKB causes Glycogen breakdown (T/F)False- it causes glycogen synthesis
- 16PKB increases protein synthesis (T/F)True
- 17PKB phosphorylates Glycogen Synthase Kinase (T/F)True- this prevents the deactivation of glycogen synthase
- 18PDK1 directly phosphorylates PKB (T/F)True
- 19What allows the different proteins to bind to T.K?The aa surrounding the tyrosine kinase
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- Year 2 Flashcards on PKB Activation Through RAS, created by gina_evans0312 on 05/11/2013.
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