Regarding HIV infection all of the following are true except

Replication of HIV occurs in activated T and B cells

It is retrovirus that infects CD4 T cells, dendritic cells and macrophages and binds to gp120

gp 120 changes conformation and binds co-receptors CCR5 and CXCR4

Reverse transcriptase copies viral ssRNA genomes into ds cDNA

A genetic deficiency of the co-receptor CCR5 confers resistance to HIV infection in vivo

All of the following are seen in a typical course of HIV infection except

Opportunistic infections will begin to arise when CD4 T cell count goes below 400 cell/cubic mm

Infected CD4 cells die as a result of viral replication

There is a latent viral reservoir in the lymphoid tissue

gp 120 expressed on infected cell binds CD4 on uninfected cell and they fuse forming multinucleated giant cells in HIV infected brain

HAART (Highly Active Anti-retroviral Therapy) = 1 NRTIs + a PI/NNRTI/II

Block Reverse Transcriptase - Blocks integration

Block maturation (gp 160 -> gp41)

Quiz

ivenkat 4 perguntas

Fazer o quiz

1Regarding HIV infection all of the following are true except
1. AIt is retrovirus that infects CD4 T cells, dendritic cells and macrophages and binds to gp120
2. Bgp 120 changes conformation and binds co-receptors CCR5 and CXCR4
3. CReverse transcriptase copies viral ssRNA genomes into ds cDNA
4. DReplication of HIV occurs in activated T and B cells
5. EA genetic deficiency of the co-receptor CCR5 confers resistance to HIV infection in vivo
2All of the following are seen in a typical course of HIV infection except
1. AInfected CD4 cells die as a result of viral replication
2. BThere is a latent viral reservoir in the lymphoid tissue
3. Cgp 120 expressed on infected cell binds CD4 on uninfected cell and they fuse forming multinucleated giant cells in HIV infected brain
4. DOpportunistic infections will begin to arise when CD4 T cell count goes below 400 cell/cubic mm
3You need 2 positive ELISA and a confirmatory positive Western Blot to confirm HIV positive status
1. AVerdadeiro
2. BFalso
4All of the following are true about HIV drugs except?
1. ABlock CCR5 - will block fusion
2. BBlock Reverse Transcriptase - Blocks integration
3. CBlock maturation (gp 160 -> gp41)
4. DHAART (Highly Active Anti-retroviral Therapy) = 1 NRTIs + a PI/NNRTI/II