Hypersensitivity reactions

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Quiz by ivenkat, updated more than 1 year ago
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Created by ivenkat over 6 years ago
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Description

All four hypersensitivity reactions

Resource summary

Question 1

Question
All of the following are correctly matched except?
Answer
  • Type I HSR - IgE mediated
  • Type II HSR - IgA mediated
  • Type III HSR - Immune complex - IgG mediated
  • Type IV HSR - Cell mediated

Question 2

Question
All of the following are true about hygiene hypothesis except
Answer
  • Excessive hygeine
  • Overuse of antibiotics
  • Not vaccinating the child

Question 3

Question
All of the following are components of a typical adaptive response to an helminthic infection except
Answer
  • CDH4 Th1 cells
  • Cytokines - IL 3,4,5,9,10,13
  • antibodies IgE and IgG 1 and 4
  • Effector cells such as eosinophils, basophils and mast cells

Question 4

Question
The main components of type I HSR are neutrophils and lymphocytes
Answer
  • True
  • False

Question 5

Question
Sensitization to antigen involves class switching to IgE production on first contact with an allergen
Answer
  • True
  • False

Question 6

Question
All of the following are stages in HSR I except
Answer
  • Initial exposure to immunogen which results in the production of reactive B and T cells - no symptoms
  • B cell - T cell interaction - antigen activation of Th2 cells
  • Production of IL 4 + IL 13
  • Production of IgE
  • Binding of IgE to Fc Epsilon Receptor and activation/sensitization of mast cell and release of mediators
  • None of the above

Question 7

Question
The following is true about HSR I immediate and late response
Answer
  • Within minutes mast cell + Basophils will release histamine and serotonin causing wheal and flare
  • In hours Eosinophils +Th2 will release second wave of mediators prostaglandis and leukotrienes
  • Both are correct
  • None of the above

Question 8

Question
Intrinsic asthma is Type I HSR reaction
Answer
  • True
  • False

Question 9

Question
The Primary method for diagnosing HSR I is by skin testing, with the characteristic response being "wheal and flare" reaction within minutes
Answer
  • True
  • False

Question 10

Question
RAST detects IgG anti-allergen in patient's serum
Answer
  • True
  • False

Question 11

Question
All of the following are used as treatment strategies for HSR I
Answer
  • Allergen avoidance
  • Correct Th1/Th2 imbalance (not clinically feasible)
  • Block mediators either with antihistamine, lipoxygenase inhibition or steroid use
  • Correct isotype switch to IgE
  • Prevent IgE binding to mast cells to prevent IgE mediated degranulation

Question 12

Question
Epinephrine is the main treatment for anaphylaxis - true or false
Answer
  • True
  • False

Question 13

Question
In desensitization treatment the allergen binds to IgG thereby preventing IgE mediated response - true or false
Answer
  • True
  • False

Question 14

Question
Omalizumab is a mab that binds to Fc region of IgE thereby blocking the arming of mast cells - true or false
Answer
  • True
  • False

Question 15

Question
All of the following are true about HSR II except
Answer
  • HSR II is mediated by IgG or IgM not IgE
  • HSR II the antibodies bind to the self antigen on cell membranes and extracellular matrix
  • HSR II makes autoreactive antibodies
  • HSR II activates the alternate complement pathway

Question 16

Question
All of the following are mechanisms for cell damage in HSR II except?
Answer
  • recruitment of neutrophils - causing tissue injury and inflammation
  • Opsonization and Phagocytosis
  • Interfere with cellular functions - either block or stimulate cell receptors
  • All of the above
  • None of the above

Question 17

Question
All of the following are HSR II reactions except
Answer
  • Hemolytic disease of the newborn
  • Blood transfusion reactions
  • Penicillin reaction
  • Extrinsic asthma

Question 18

Question
All of the following are true regarding Hemolytic disease of the newborn (HDNB) except
Answer
  • Seen when mother is Rh+ and baby is Rh-
  • Mother is O type blood group and baby A,B or AB
  • Prevention is by giving Rhogam to the mother
  • None of the above

Question 19

Question
All of the following are non cytotoxic type II HSR diseases except
Answer
  • Myasthenia gravis
  • NDIIM
  • Graves disease
  • Pernicious anemia
  • Penicillin allergy

Question 20

Question
All of the following are cytotoxic HSR II except?
Answer
  • Erythroblastosis fetalis (Hemolytic disease of the newborn)
  • PCN reaction
  • Rheumatic fever
  • Autoimmune thrombocytopenic purpura
  • Goodpasture syndrome
  • Grave's disease

Question 21

Question
Type III HSR - damaged tissues are innocent bystanders when a circulating (soluble antigen) immune complex becomes deposited in the tissues - true or false
Answer
  • True
  • False

Question 22

Question
When immune complexes (ICs) exceed disposal the net result is inflammation locally or systemically - true or false
Answer
  • True
  • False

Question 23

Question
All of the following are Type III HSR except
Answer
  • Serum sickness
  • Farmer's lung (Arthus reaction)
  • SLE
  • Post Streptococcal glomerulonephritis (PSGN)
  • None of the above

Question 24

Question
Lumpy bumpy pattern of nephritis is characteristic of PSGN - true or false
Answer
  • True
  • False

Question 25

Question
All of the following are true about Arthus reaction except?
Answer
  • Farmer's lung is an example of Arthus reaction
  • Arthus reaction is used in the skin testing of HSR III
  • Arthus reactions are visualized in the skin
  • none of the above

Question 26

Question
All of the following are true about delayed type IV HSR except?
Answer
  • Starts 49-72 hours after antigen exposure
  • T cell release cytokines that activate macrophages resulting in cell damage
  • B cells form antibodies that are delayed in their response hence called delayed HSR
  • Mediated by Th1 cells and CD8+ cytotoxic T cells

Question 27

Question
HSR IV is an inappropriate manifestation of DTH response that normally protects against intracellular bacterial and fungal infections - true or false
Answer
  • True
  • False

Question 28

Question
All of the following are examples of IV HSR except
Answer
  • PPD
  • Poison ivy dermatitis
  • contact dermatitis due to nickel exposure
  • Celiac disease
  • PSGN
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